. home.aspx

NEWS

home.aspx
   


Researchers unlock potential to use CRISPR to alter the microbiome

October 04, 2019 / Crystal MacKay

Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted attack on specific bacteria. Published today in Nature Communications, this study opens up the possibility of using CRISPR to alter the makeup of the human microbiome in a way that could be personalized and specific from person to person. It also presents a potential alternative to traditional antibiotics to kill bacteria like Staphyloccous aureus (Staph A) or Escherichia coli (E. coli). "One of the major reasons that I am excited about this work is that it has a wide range of possible real-world applications," said Bogumil Karas, Ph.D., Assistant Professor at Western's Schulich School of Medicine & Dentistry. "It has the potential for development of next generation antimicrobial agents that would be effective even for bacteria that are resistant to all known antibiotics. This techn...