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New method for imaging biological molecules

September 06, 2019 / Phys.org

Researchers at Karolinska Institutet in Sweden, together with colleagues from Aalto University in Finland, have developed a new method for creating images of molecules in cells or tissue samples. The method is based on the use of DNA snippets and is called DNA microscopy. The approach is currently described in the scientific journal PNAS. The new method involves researchers in the first stage mixing up a cell or tissue sample with short sequences of single-stranded DNA, selected to attach to the specific molecules that are going to be studied. If it for example involves a specific protein that is going to be investigated, small DNA snippets are used that bind to this particular protein. In the next stage, enzymes are fed to the short DNA sequences to connect and form DNA molecules.