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Multiple Sclerosis Suppressed in Mouse Model by Oft-Overlooked Immune System Cell Type

August 08, 2019 / GEN

Scientists at Stanford University School of Medicine have identified a type of immune system cell that may point to the development of new therapeutic strategies against autoimmune disorders such as multiple sclerosis MS and celiac disease. Findings from the teams studies in a mouse model of MS, along with preliminary analyses of cells from patients with MS, indicated that a subset of CD8+ T cells a type of immune system cell that typically acts to kill infected or cancer cells may act to suppress the pathogenic CD4+ and γδ+ T cells that promote autoimmune disease. Their results suggest that inflammatory and suppressive immune cells work to balance each other, and that selectively activating the suppressive CD8+ T cells during autoimmune diseases may restore the balance. “We absolutely think that something like this is happening in human autoimmune diseases,” commented research lead Mark Davis, PhD, professor of microbiology and immunology, who holds the Burt an...