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Melanoma Immunotherapy Enhanced by Targeting Treg Cell Control Protein

January 08, 2020 / Genetic Engineering and Biotechnology News

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a new potential strategy for boosting the immune system’s ability to fight cancer. Studies in gene knockout mice, carried out in collaboration with a team at NYU Langone’s Perlmutter Cancer Center, suggested that a protein known as Siah2 is involved in the control of T regulatory cells (Tregs) that limit the effectiveness of anticancer immunotherapies. The study findings indicate that targeting Siah2 may enhance the effectiveness of immune checkpoint inhibition using anti-PD-1 therapy, in cases where treatment would otherwise fail.