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How CBD Blocks THC Euphoria Explained

October 01, 2019 / GEN

With widespread legal approval of marijuana growing, scientific research into some of the more elusive details of this drug can be explored. For instance, it has been previously shown that strains of cannabis with high levels of tetrahydrocannabinol (THC) and low levels of cannabidiol (CBD) can cause increased psychiatric effects, including paranoia, anxiety, and addictive-behaviors. Yet, why this occurs had been a mystery until now, as investigators from the University of Western Ontario, recently showed for the first time the molecular mechanisms at work that cause CBD to block the psychiatric side-effects caused by THC. “For years we have known that strains of cannabis high in THC and low in CBD were more likely to cause psychiatric side-effects,” explained senior study investigator Steven Laviolette, PhD, a professor at Western’s Schulich School of Medicine & Dentistry. “Our findings identify for the first time the molecular mechanisms by which CBD may a...