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Gene Therapy Molecular Switch May Control Dosing

December 26, 2019 / Genetic Engineering and Biotechnology News
SHARESHARESHARE

The field of gene therapy is full of promise, with many therapies for genetic diseases currently being tested in clinical trials. Despite this excitement, there are still some stumbling blocks to bringing these gene therapies to patients. One limitation is the lack of small genetic switches with wide dynamic ranges that would allow for the control of transgene expression without the requirement of additional protein components. But, now, a team from the Scripps Research in Jupiter have developed a special molecular switch that could be embedded into gene therapies to control dosing. This new tool may offer gene therapy designers what may be the first viable technique for adjusting the activity levels of therapeutic genes.