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DNA Has Relatively Little Say in Disease Risk (Usually)

December 30, 2019 / Genetic Engineering and Biotechnology News
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Many diseases have been associated with common gene mutations, or single nucleotide polymorphisms (SNPs). But how well do SNPs or SNP combinations predict disease risk? Not very well at all, say scientists based at the University of Alberta. These scientists, led by David Wishart, PhD, the study’s senior author and a professor of biological sciences and computing science, suggest that disease risk could be better predicted by evaluating clinical, metabolite, or protein measures. “It is becoming increasingly clear,” explained Wishart, “that the risks for getting most diseases arise from your metabolism, your environment, your lifestyle, or your exposure to various kinds of nutrients, chemicals, bacteria, or viruses.”