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THE SUCCESSFUL EVOLUTION OF BIOTHERAPIES FROM DISCOVERY TO DEVELOPMENT

February 27, 2020 | (10:00 AM)
USA (United States of America)
SHARESHARESHARE
A large portion of biologics fail during development due to issues with efficacy, safety, or manufacturability. Evaluating potential liabilities as early as possible during the molecule design and lead selection phases can greatly increase the chances of identifying a successful candidate. Initial strategies to optimize the amino acid sequence of the molecule will be discussed along with techniques to maximize product quality through expression vector design.