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SINGLE-CELL TRANSCRIPTOMIC ATLAS OF THE HUMAN RETINA IDENTIFIES CELL TYPES ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION

October 23, 2019
USA (United States of America)
Age-related macular degeneration (AMD) is one of the leading causes of blindness in the elderly. Although genome-wide association studies have identified genetic variants associated with AMD, it has been challenging to identify the cell types driving this genetically complex disease. We performed single-cell RNA sequencing (scRNA-seq) of normal human retinas, and report the first single-cell human retinal transcriptomic atlas identifying all major cell types.