The role of immune cells in the formation of metastases

Medical Xpress | February 06, 2019

Tumor cells use a certain type of immune cell, so-called neutrophils, to enhance their ability to form metastases. Scientists from the University of Basel and the University Hospital of Basel have deciphered the mechanisms of this collaboration and found strategies for blocking them. The results are published in Nature. A better understanding of the features that define the interplay between cancer cells and immune cells is key to identifying new cancer therapies. Yet, the focus is often given to those interactions that occur within the primary tumor and its microenvironment, while the role of immune cells during cancer dissemination in patients remains largely uncharacterized.
For example, certain immune cells, the so-called neutrophils, often enter into an alliance with tumor cells that contributes significantly to the development of metastases. This was reported by Prof. Nicola Aceto's interdisciplinary research team at the Department of Biomedicine of the University of Basel and the University Hospital of Basel.

Spotlight

Effective drug discovery and development relies in large part on the availability of predictive preclinical model systems. Application of human cellular models from tissues which are difficult to access, such as cardiomyocytes and neurons, is still challenging. Technologies based on human induced pluripotent stem cells (hiPSC) hold great promises.

Spotlight

Effective drug discovery and development relies in large part on the availability of predictive preclinical model systems. Application of human cellular models from tissues which are difficult to access, such as cardiomyocytes and neurons, is still challenging. Technologies based on human induced pluripotent stem cells (hiPSC) hold great promises.

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MEDICAL

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BioAgilytix | August 17, 2021

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MEDTECH

Ligand Pharmaceuticals Selects Landing AI's LandingLens Visual Inspection Software Platform to Enhance the Antibody Discovery Platforms

Ligand Pharmaceuticals | July 29, 2021

Landing AI announced today that it has entered into a software licensing deal with Ligand Pharmaceuticals Incorporated to integrate LandingLens into Ligand's OmniAb and xPloration antibody discovery platforms. LandingLens is a software platform that offers an end-to-end process for developing, experimenting and delivering AI-powered visual inspection solutions. The new AI-powered tools enhance Ligand's high-throughput single B cell screening accuracy and throughput in a wide range of complex biological assays, possibly increasing the output of antibodies with desired characteristics in less time. "Landing AI, led by world-renowned AI pioneer Andrew Ng, is a proven and trusted partner in enabling their clients to achieve the business value of computer vision," says Bob Chen, Ph.D., Ligand Pharmaceuticals' Director, Systems Engineering. "We selected Landing AI because of its unique data-centric approach, which puts collecting high-quality data at the core of AI development. Notably, the LandingLens software platform includes plenty of data preparation tools and features that enable us to create reliable and consistent datasets that we can iterate on over time to improve our existing AI systems continuously." "Deep learning and AI have emerged as strong technologies for enabling a wide range of vision-based applications. We are happy to be working with Ligand Pharmaceuticals and are dedicated to providing the best tools to assist our customers in unlocking the promise of AI, "said John Reuter, Landing AI's Vice President of Sales. About Ligand Pharmaceuticals Ligand is a revenue-generating biopharmaceutical company that focuses on creating or acquiring technologies that aid pharmaceutical companies in discovering new medicines. Ligand's business strategy adds value to stockholders by offering a diverse portfolio of biotech and pharmaceutical product revenue streams backed by an efficient and low corporate cost structure. Ligand's goal is to provide investors with the chance to participate in the biotech industry's promise through a profitable, diversified, and lower-risk business than a typical biotech firm. Ligand's business strategy is built on what the company specializes in drug discovery, early-stage drug development, product reformulation, and partnering. In addition, Ligand collaborates with other pharmaceutical firms to capitalize on their capabilities (late-stage development, regulatory management, and commercialization) to generate revenue. About AI Landing Using enablement tools, Landing AI enables clients to realize the business and operational benefits of computer vision. LandingLens, the company's main product, is an enterprise MLOps system that enables end-to-end processes for developing, iterating, and deploying AI-powered visual inspection solutions. As data quality is important to the achievement of production AI systems, LandingLens includes plenty of specially designed data preparation tools and processes to assist users in achieving optimum data accuracy and consistency. Dr. Andrew Ng, the co-founder of Coursera, former chief scientist of Baidu, and founding lead of Google Brain, founded Landing AI, guided by a data-centric AI approach, and is uniquely positioned to help companies successfully move their AI projects from proof-of-concept to full-scale production.

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INDUSTRIAL IMPACT

Omega Therapeutics Announces Strategic Research Collaboration with Stanford University School of Medicine

Omega Therapeutics, Inc | October 14, 2021

Omega Therapeutics, Inc. ("Omega"), a development-stage biotechnology company pioneering the first systematic approach to use mRNA therapeutics as programmable epigenetic medicines by leveraging its OMEGA Epigenomic Programing™ platform, today announced a strategic research collaboration with researchers at the Stanford University School of Medicine to explore the therapeutic potential of Omega Epigenomic Controllers (OECs) to control ocular disease genes associated with inflammation or regeneration of ocular tissues. Under the terms of the collaboration, Omega and members of the Ophthalmology Department of Stanford University School of Medicine will use the OMEGA Epigenomic Programming platform to discover and research novel ocular targets for potential future OEC development candidates. Albert Wu, M.D., Ph.D., FACS, Associate Professor of Ophthalmology, will serve as principal investigator. Other contributors will include Jeffrey Goldberg, M.D., Ph.D., Professor and Chair of Ophthalmology, and Michael Kapiloff, M.D., Ph.D., Associate Professor (Research) of Ophthalmology. "Through this research collaboration, we aim to expand the reach of our OMEGA platform within regenerative medicine, immunology, and inflammation with ocular disease targets. We will continue exploration of the broad potential of our disruptive platform and OECs, our new class of mRNA therapeutics as programmable epigenetic medicines." Mahesh Karande, President and Chief Executive Officer of Omega Therapeutics About Omega Therapeutics Omega Therapeutics is a development-stage biotechnology company pioneering the first systematic approach to use mRNA therapeutics as programmable epigenetic medicines by leveraging its OMEGA Epigenomic Programming™ platform. The OMEGA platform harnesses the power of epigenetics, the mechanism that controls gene expression and every aspect of an organism's life from cell genesis, growth and differentiation to cell death. The OMEGA platform enables control of fundamental epigenetic processes to correct the root cause of disease by returning aberrant gene expression to a normal range without altering native nucleic acid sequences. Omega's engineered, modular, and programmable mRNA-encoded epigenetic medicines, Omega Epigenomic Controllers™, target specific intervention points amongst the thousands of mapped and validated novel DNA-sequence-based epigenomic loci to durably tune single or multiple genes to treat and cure disease through Precision Genomic Control™. Omega is currently advancing a broad pipeline of development candidates spanning a range of disease areas, including oncology, regenerative medicine, multigenic diseases including immunology, and select monogenic diseases.

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