Synlogic and Roche Partner for Immuno-Oncology Combination Therapy for Solid Tumors

Roche | May 22, 2019

Cambridge, Mass.-based Synlogic is partnering with Roche to develop Synlogic’s SYNB1891 with Roche’s checkpoint inhibitor Tecentriq (atezolizumab) in advanced solid tumors. Synlogic plans to file an Investigational New Drug (IND) with the U.S. Food and Drug Administration (FDA) in the second half of this year. SYNB1891 is a non-pathogenic strain of the bacterium E. coli that has been engineered to express a Stimulator of Interferon Genes (STING) agonist, which stimulates the innate immune system. When bacteria are enveloped by antigen-presenting cells within a tumor, the STING pathway is activated, which results in a type 1 interferon (IFN) response and the beginning of tumor-specific T-cell responses. In other words, it stimulates the immune system.

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Innovations, Intellectual Property in Pintels DNA Diagnostics Analytics. Global DNA Diagnostics Innovations Diagnostics is important technology sector of life.

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