Study finds way to potentially improve immunotherapy for cancer

Medical Xpress | February 20, 2019

A new study has identified a drug that potentially could make a common type of immunotherapy for cancer even more effective. The study in laboratory mice found that the drug dasatinib, which is FDA-approved to treat certain types of leukemia, greatly enhances responses to a form of immunotherapy that is used against a wide range of other cancers. "If our findings are confirmed in clinical trials, it means that by combining both types of drugs, we may be able to better shrink or even eliminate tumors in bladder, breast, colon, melanoma and sarcoma cancers," said corresponding author Dan Theodorescu, MD, Ph.D., director of Cedars-Sinai Cancer. The study was published today in Science Advances.
Immunotherapies are designed to help patients' own immune systems fight various cancers. The study focused on one class of immunotherapy called checkpoint inhibitors, which involve a protein called PD-1. This protein acts as an off switch to keep immune cells known as T-cells from attacking normal cells in the body when they come in contact with another similarly named protein, PD-L1. Normal cells have PD-L1, which tells the T-cells not to attack them. Cancer cells, however, have especially large amounts of PD-L1, which serves to deceive T-cells into thinking the cancer cells are normal.

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