Senescent Cells Promote Blood Clotting

GEN | September 26, 2019

Flawed cells may enter senescence, or cell cycle arrest, to avoid passing on their flaws, but they can still cause trouble. Accumulating year by year and staying metabolically active while secreting harmful factors, senescent cells contribute to various age-related diseases. So far, the factors that contribute to inflammation have attracted the most attention. But a new set of factors has been uncovered by researchers at the Buck Institute. These factors appear to participate in hemostasis. It is probably no coincidence, then, that risks for certain hemostasis-related disorders, such as thrombosis, increase with age. Another intriguing correlation exists, various research teams have noted, between the administration of cancer drugs, which damage DNA and induce cellular senescence, and an increased risk of developing blood clots. Despite these correlations, scientists have hesitated to cite a link between cellular senescence and thrombosis. Before positing such a link, scientists would prefer to have supporting evidence—evidence of the sort that has been sought, and found, by a Buck Institute team led by Judith Campisi, PhD, a professor of biogerontology.

Spotlight

This paper explores some of the major challenges facing the pharmaceutical industry today. Four Major Challenges Facing the Pharmaceutical Industry: - Delivering shareholder/stakeholder value -Low growth business environment .-R&D productivity - Rising risks and loss of trust.

Spotlight

This paper explores some of the major challenges facing the pharmaceutical industry today. Four Major Challenges Facing the Pharmaceutical Industry: - Delivering shareholder/stakeholder value -Low growth business environment .-R&D productivity - Rising risks and loss of trust.

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