Scientists advance creation of 'artificial lymph node' to fight cancer, other diseases

phys.org | April 18, 2019

In a proof-of-principle study in mice, scientists at Johns Hopkins Medicine report the creation of a specialized gel that acts like a lymph node to successfully activate and multiply cancer-fighting immune system T-cells. The work puts scientists a step closer, they say, to injecting such artificial lymph nodes into people and sparking T-cells to fight disease. In the past few years, a wave of discoveries has advanced new techniques to use T-cells—a type of white blood cell—in cancer treatment. To be successful, the cells must be primed, or taught, to spot and react to molecular flags that dot the surfaces of cancer cells. The job of educating T-cells this way typically happens in lymph nodes, small, bean-shaped glands found all over the body that house T-cells. But in patients with cancer and immune system disorders, that learning process is faulty, or doesn't happen. To address such defects, current T-cell booster therapy requires physicians to remove T-cells from the blood of a patient with cancer and inject the cells back into the patient after either genetically engineering or activating the cells in a laboratory so they recognize cancer-linked molecular flags.

Spotlight

Today’s Pharma and Bio-Tech supply chain is more complex than ever! Multiple events occurring on a daily basis are shaping the competitive and regulatory environment in which channel members operate their business. ASP regulation is changing, and non-conventional players (such as 3PLs) are threatening to dis-intermediate conventional players.

Spotlight

Today’s Pharma and Bio-Tech supply chain is more complex than ever! Multiple events occurring on a daily basis are shaping the competitive and regulatory environment in which channel members operate their business. ASP regulation is changing, and non-conventional players (such as 3PLs) are threatening to dis-intermediate conventional players.

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INDUSTRIAL IMPACT

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