Researchers identify causal variants in blood cells and tie them with genetic mechanisms

Medical Xpress | March 13, 2019

A team of researchers affiliated with multiple institutions in and around the Boston area in the U.S. and one in Finland has identified hundreds of possible causal variants associated with blood cell traits and tied them to important blood-related mechanisms. The team sought to learn more about genetic variants in blood cells that are responsible for blood mechanisms such as which genes are responsible for regulating the number of white blood cells, and which regulate the optimal number of white blood cells for an individual. To that end, they conducted a genome-wide association study (GWAS) by accessing data in the UK Biobank, which provided information regarding blood cell characteristics such as hemoglobin levels, white cell count and platelet count. The data represent health information for approximately 115,000 people in the United Kingdom. The traits the team focused on centered around those involved in hemopoiesis (production of blood cells and platelets), which occurs in bone marrow.

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Spotlight

At Fisher BioServices, we specialize in the management of critical biological materials in support for the advancement of cell therapy, high value biologics, and population-based public health research. Our state-of-the-art infrastructure allows us to develop storage configurations for a multitude of biologics and ensure our clients’ material is properly managed. We provide customized end-to-end chain of custody solutions for our large pharmaceutical clients and partners in academia and government, ensuring the integrity and efficacy of their valued material from the manufacturer to the bedside

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