Researchers find new way to find antibiotics in dirt

Phys.org | September 16, 2019

Researchers at McMaster have designed a new way to rapidly identify antibiotics hidden in common dirt. Their method, published today in Nature Biotechnology, may help guide drug discovery by allowing researchers to reassess the potential of bacteria that have already been mined for rare or new compounds with antibiotic activity. The goal is to develop the medicines in response to the current global antimicrobial resistance crisis. "Most of the antibiotics in clinical use today derive from bacteria and fungi that live in the soil, but we know that these microbes have the capacity to make many more compounds than just the ones we keep rediscovering," said Elizabeth Culp, co-principal author and a McMaster Ph.D. candidate in biochemistry. "Our study describes a way to essentially 'weed out' the most common antibiotics made by soil bacteria to unearth their hidden antibiotic potential." The team is led by senior author and professor Gerry Wright at the David Braley Centre for Antibiotic Discovery within the Michael G. DeGroote Institute for Infectious Disease Research.

Spotlight

Stem cells are special human cells that have the ability to develop into many different cell types, from muscle cells to brain cells.

Spotlight

Stem cells are special human cells that have the ability to develop into many different cell types, from muscle cells to brain cells.

Related News

MEDICAL

AlgaEnergy Agreements with Laboratoire M2 for Distribution and Product Development

AlgaEnergy | January 14, 2021

AlgaEnergy N.A. Inc., the U.S. subsidiary of Spain-based AlgaEnergy S.A. furthermore, a worldwide pioneer in microalgae biotechnology, has marked worldwide item conveyance and item improvement concurrences with Laboratoire M2 Inc., a Quebec-based biotechnology organization that creates normal and practical disinfectant items, including THYMOX CONTROL® fungicide and bactericide. AlgaEnergy formulates and creates incredible, manageable, microalgae-based yield contributions for the world's producers. Laboratoire M2's THYMOX® items, gotten from the antimicrobial intensity of thyme oil and other regular oils, are utilized in harvest and indoor farming, just as in turf and nursery markets. Under the arrangements, AlgaEnergy will acquire restrictive worldwide rights to disperse the THYMOX crop insurance product offering through AlgaEnergy's specialty units in key rural business sectors in Europe, the Americas, Africa and Asia-Pacific. The two organizations likewise marked a permit and collective item advancement understanding under which their logical groups will together attempt to make new, value-added biocontrol products.

Read More

Obsidian Therapeutics Announces Bristol Myers Squibb Opt-In of cytoDRiVE™ Cell Therapy Candidate

Obsidian Therapeutics | September 16, 2020

Obsidian Therapeutics, Inc., a biotechnology company pioneering controllable cell and gene therapies, today announced that Bristol Myers Squibb (NYSE:BMY) has exercised its option to an exclusive worldwide license to a cell therapy candidate based on Obsidian's cytoDRiVE™ technology for the controlled expression of the immunomodulatory factor CD40L. This announcement marks the first opt-in decision by Bristol Myers Squibb since the companies announced their collaboration to develop novel cell therapies in January 2019. Under the terms of the agreement, Obsidian is eligible to receive potential future milestone and royalty payments. "We are very interested in exploring innovative approaches to developing engineered cell therapies, including the cytoDRiVE™ platform," said Rupert Vessey, D. Phil., Executive Vice President, Research and Early Development, Bristol Myers Squibb.

Read More

CELL AND GENE THERAPY

Vizgen Releases Commercial MERSCOPE Platform

Vizgen | August 31, 2021

Vizgen, the life science company dedicated to improving human health by visualizing single-cell spatial genomics information, today announced shipment of the first commercial MERSCOPETM Platforms, marking the successful start of their limited summer release program. These first platforms are being purchased by leading research institutes including the Salk Institute, the University of California, Irvine, and the Beth Israel Deaconess Medical Center. Vizgen will continue shipping a limited number of commercial instruments for the next several months before releasing MERSCOPE to the U.S. market at large in late 2021. MERSCOPE is the first commercially available high-plex single-cell spatial genomics platform, and the only platform for MERFISH technology. Developed in the laboratory of Dr. Xiaowei Zhuang, a Howard Hughes Medical Institute Investigator, and David B. Arnold, Jr. Professor of Science at Harvard University, MERFISH provides the highest detection efficiency available for spatially profiling gene expression across whole tissues and resolving individual transcripts with nanometer-scale resolution through combinatorial labeling, sequential imaging, and error-robust barcoding. “This is a revolutionary time for the field of genomics. Researchers across the country are now able to access the spatial dimension to answer new kinds of scientific questions and make significant biological discoveries,” said Terry Lo, President and CEO of Vizgen. “Profiling the expression of hundreds of genes, in hundreds of thousands of cells, for hundreds of millions of transcripts all while retaining the spatial information within the tissue architecture has never been done before. What was previously unimaginable, MERSCOPE now makes routine.” About Vizgen Vizgen is dedicated to pioneering the next generation of genomics, providing tools that demonstrate the possibilities of in situ single cell spatial genomics, setting the standard for the spatial genomics field. These tools are enabling researchers to gain new insight into the biological systems that govern human health and disease with spatial context. The company's MERSCOPETM platform enables massively multiplexed, genome-scale nucleic acid imaging with high accuracy and unrivaled detection efficiency at subcellular resolution. MERSCOPE provides transformative insight into a wide range of tissue-scale basic research and translational medicine in oncology, immunology, neuroscience, infectious disease, developmental biology, cell and gene therapy, and is an essential tool for accelerating drug discovery and development.

Read More