Researchers discover new type of blood vessel in the bones of mice

Medical Xpress | January 23, 2019

A team of researchers affiliated with multiple institutions across Germany has discovered a new type of blood vessel in mouse bones. In their paper published in the journal Nature Metabolism, the group describes making sample mouse bones transparent, as well as their microscopic properties. Christopher Ritchlin and Iannis Adamopoulos with the University of Rochester and the University of California, respectively, have written a News and Views piece on the work done by the team in the same journal issue. Several years ago, doctors in the military discovered that medicine injected directly into large bones very quickly circulated through the bodies of wounded soldiers with blood flow problems. The mechanism has been a mystery that the researchers in this new effort sought to solve.
To find out what happens with blood flow in bones, the researchers injected mice with a chemical that makes the bone nearly transparent. That allowed a better view under light-sheet fluorescence and X-ray microscopy to study blood movement. The researchers found thousands of very tiny channels in the bone that led from the marrow to the bloodstream—the team described the channels as trans-cortical vessels (TCVs). The channels were found to be a type of capillary, carrying blood and immune cells from the bone to the bloodstream. The researchers report that their calculations suggest the TCVs may be the main blood carrier in bones.

Spotlight

Lipids play a structural role in organisms, forming cells and organelles’ membranes. Due to their implication in widespread pathologies such as cancer or inflammation, they are gaining considerable interest within the scientific community.

Spotlight

Lipids play a structural role in organisms, forming cells and organelles’ membranes. Due to their implication in widespread pathologies such as cancer or inflammation, they are gaining considerable interest within the scientific community.

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EVONETIX LTD | March 02, 2022

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RESEARCH

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Vipergen ApS, Anavo Therapeutics | May 18, 2021

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HealthMyne's Radiomic Technology Leveraged to Identify Biomarkers That Predict Immunotherapy Treatment Responses

HealthMyne | September 22, 2021

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