Researchers discover key protein in the production of insulin

Medical Xpress | January 28, 2019

The crucial hormone insulin needs help to acquire the right structure. A protein that assists in the process of insulin folding has just been discovered in a new study conducted by researchers at the Department of Biomedical Sciences, University of Copenhagen. They hope the new research results can be used to develop treatments for conditions such as increased level of insulin in the blood known as hyperinsulinemia. Even though researchers have been familiar with and studied the hormone insulin for more than a hundred years, especially in connection with diabetes, they still make new discoveries concerning the hormone. Now researchers from the Faculty of Health and Medical Sciences at the University of Copenhagen have uncovered a hitherto unknown process in the production of insulin. The new research results have just been published in the scientific journal Diabetes.
Insulin is produced in the beta cells of the pancreas. The hormone is produced as a precursor called proinsulin. For proinsulin to mature into functional insulin, it needs to be folded and processed correctly to acquire the right structure with assistance from proteins that are termed chaperones. The researchers have now discovered and identified such a chaperone. A proinsulin chaperone termed glucose-regulated protein GRP94.

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A preliminary study was undertaken by ABLE to understand the density of biotech start-ups (as per the definition prescribed by Start-up India policy). A key finding of the study is that the number of start-ups in the biotechnology space between January 1, 2012 and December 31, 2016 is over 1022. It maybe recalled that industry, policy makers, and the other stakeholders in the country, a few years ago around 2012-13, had identified “startups” as one of the important drivers for biotech’s growth in future. At one of the deliberations between industry and the Department of Biotechnology (DBT), the participating leaders did a quick calculation and suggested a target of creating 2000 biotech start-ups by 2020. This was to promote innovation and R&D. This was accepted as a guidance number. ABLE decided to do a quick study to find out the status of start-ups and check if the industry is on track?

Spotlight

A preliminary study was undertaken by ABLE to understand the density of biotech start-ups (as per the definition prescribed by Start-up India policy). A key finding of the study is that the number of start-ups in the biotechnology space between January 1, 2012 and December 31, 2016 is over 1022. It maybe recalled that industry, policy makers, and the other stakeholders in the country, a few years ago around 2012-13, had identified “startups” as one of the important drivers for biotech’s growth in future. At one of the deliberations between industry and the Department of Biotechnology (DBT), the participating leaders did a quick calculation and suggested a target of creating 2000 biotech start-ups by 2020. This was to promote innovation and R&D. This was accepted as a guidance number. ABLE decided to do a quick study to find out the status of start-ups and check if the industry is on track?

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ImaginAb | November 23, 2022

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Gamma Biosciences and Lonza Collaborate to Co-develop Reagents for Clinical Cell Selection in the Cocoon® Platform

Gamma Biosciences | October 13, 2022

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Heska to Acquire LightDeck Diagnostics to Invest in Manufacturing Capabilities and Accelerate Research and Development Efforts

LightDeck Diagnostics and Heska | September 13, 2022

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