INDUSTRY OUTLOOK

RegeneRx Licensee Acquired by Korean Biopharmaceutical Group

RegeneRx Biopharmaceuticals, Inc. | September 28, 2021

RegeneRx Biopharmaceuticals, Inc., a clinical-stage drug development company focused on tissue protection, repair and regeneration), announced that GtreeBNT, the licensee for several RegeneRx products, is being acquired by HLB Group, a Korean company that includes six biopharmaceutical and financial subsidiaries in Korea and the U.S.

GtreeBNT announced that as part of its acquisition the company would issue approximately US$80 million of new stock and convertible bonds to HLB Group to fund ongoing programs. The new capital should speed up the clinical trials currently in progress and allow the company to focus on new drug approval. RGN-259 will remain a priority for the company.

HLB's recommended executives are expected to be appointed at the general meeting scheduled for October 29, 2021. Won Yang, the current CEO of GtreeBNT, is expected to remain as the chief research officer and continue to lead the development of new drugs after the acquisition.

RegeneRx has scheduled its 2021 Annual Stockholder Meeting for November 10, 2021 and hopes to have additional details on the acquisition and its effect on GtreeBNT's clinical development activities and timing related to RGN-259 and RGN-137, products developed for the treatment of dry eye syndrome, neurotrophic keratitis, and epidermolysis bullosa.

The fact that GtreeBNT will receive a significant capital infusion related to the transaction, we believe, should benefit the development of the products we licensed to the company.  As soon as practicable after we receive any new information from the new management related to our products we will update our stockholders.

- J.J. Finkelstein, president and chief executive.

About RegeneRx Biopharmaceuticals, Inc.
RegeneRx is focused on the development of novel therapeutic peptides, including Thymosin beta 4 (Tβ4) and its constituent fragments, for tissue and organ protection, repair, and regeneration. RegeneRx currently has three drug candidates in clinical development for ophthalmic, cardiac/neuro and dermal indications, four active strategic licensing agreements in the U.S., China, and Pan Asia (Korea, Japan, and Australia, among others), and the EU, and has patents and patent applications covering its products in many countries throughout the world.

Spotlight

Research at the Department of Chemistry and Bioscience is diverse. We explore the building blocks of life to achieve new knowledge and provide platforms for industrial advances. The Department carries out education and research in chemistry, biology, biotechnology, environmental engineering and chemical engineering – including oil and gas technology. The research contributes to international state of the art and has impact on development of new technologies and products in industry.

Spotlight

Research at the Department of Chemistry and Bioscience is diverse. We explore the building blocks of life to achieve new knowledge and provide platforms for industrial advances. The Department carries out education and research in chemistry, biology, biotechnology, environmental engineering and chemical engineering – including oil and gas technology. The research contributes to international state of the art and has impact on development of new technologies and products in industry.

Related News

CELL AND GENE THERAPY

Mission Bio and S2 Genomics to Provide Tumor Sample for Single-cell DNA Analysis

Mission Bio | April 20, 2022

Mission Bio, Inc., a leader in high-throughput single-cell DNA and multi-omics analysis, announced today a co-marketing agreement with S2 Genomics, Inc., a leading developer of laboratory automation solutions for processing solid tissues for single-cell applications, to provide a single streamlined workflow for solid tumor applications from sample prep to analysis. Christine A. Iacobuzio-Donahue, MD, Ph.D., Director of the Center for Pancreatic Cancer Research at Memorial Sloan Kettering Cancer Center (MSKCC), validated the automated nuclei workflow, which she presented at the American Association for Cancer Research (AACR) Annual Meeting last week. Single-cell DNA analysis has revolutionized cancer research, allowing researchers to gain high-resolution insights into tumor heterogeneity, leading to a slew of high-profile papers on disease causes. Solid tumor profiling, on the other hand, presents significant problems, as existing prep procedures sometimes fail to yield enough cells or nuclei to offer relevant data. Mission Bio introduced their Tapestri Solution for Solid Tumor Research last month to address this issue, which includes new pre-designed research panels for breast cancer and glioblastoma multiforme, as well as an upgraded single-cell copy number variation (CNV) bioinformatic analysis tool. S2 Genomics' SingulatorTM 100 technology for automated dissociation of solid tissue into single-cell or nuclei suspensions can now be used in conjunction with Tapestri to achieve scalable, high-yield, efficient, and repeatable tissue processing. We are eager to partner with leading companies to address key challenges to sample prep in solid tumor research, As Dr. Iacobuzio-Donahue's lab demonstrates, the Singulator 100 and Tapestri together are a powerful solution enabling single-cell DNA sequencing at scale, in pancreatic cancer research and across a variety of tissue types." Yan Zhang, Ph.D., CEO of Mission Bio. The Singulator 100 has been an important tool for enabling single-cell sequencing in solid tissue, but cancer researchers have been unable to directly interrogate DNA, Tapestri is the only commercial platform capable of single-cell DNA analysis, and we're excited to offer this single automated pipeline connecting cell and nuclei prep to Tapestri's microfluidics-based workflow." John Bashkin, Chief Strategy Officer of S2 Genomics.

Read More

AI

Viva Biotech and BioMap Have Signed a Strategic Collaboration Agreement to Accelerate Early Drug Discovery Using AI Technology

Viva Biotech, BioMap | May 11, 2021

The first generation of the China Biocomputing Conference, hosted by BioMap and Adock, was successfully launched in Suzhou. The conference's goal is to bring together biotech and IT industry partners to build a multi-party integrated industrial ecosystem and realize AI's full potential in the field of biotechnology. Viva Biotech was invited to the conference and announced a strategic alliance with BioMap. This alliance will combine BioMap's AI + biological computing engine with Viva Biotech's structure-based drug discovery tool to jointly accelerate the R&D of novel drugs. Viva Biotech's President, Dr. Delin Ren, stated: "The combination of AI deep learning technologies and the SBDD technology platform is certain to have far-reaching consequences for drug design and R&D. The strategic partnership between Viva Biotech and BioMap is the ideal combination between these two technologies. It is anticipated that it will shorten the R&D period and increase the success rate of novel drug discovery." "High-quality biological data is the base of biocomputing platform development," said Liu Wei, co-founder, and CEO of BioMap. Viva Biotech has the most advanced protein structure analysis technologies and capabilities in the world. The partnership with Viva Biotech will allow BioMap to obtain high-quality macromolecular structure data in a high-throughput manner, especially for new targets, artificially designed antibody molecules, and target-drug complexes. The partnership, when combined with BioMap's strong computing power and algorithm development expertise, is expected to facilitate the development of BioMap's AI macromolecular drug platform, which will potentially lead to new drug development." AlxplorerBio and EPN, two biotech firms that Viva BioInnovator funded in and incubated, both attended the meeting and signed the collaboration agreement. About Viva Biotech Viva Biotech aims to become a place for innovative biotechnology companies from around the world. We have built a scalable business model that combines the conventional cash-for-service (CFS) model with the revolutionary equity-for-service (EFS) model. Under the CFS model, the Group offers global pharmaceutical clients a one-stop-shop for new drug discovery and production. The EFS business is committed to investing globally in biotech research that provides novel solutions to unmet medical needs in a variety of therapeutic areas. Viva Biotech has offered drug development and manufacturing services to 1,252 pharmaceutical clients worldwide as of December 31, 2020, worked on over 1,500 independent drug targets, delivered over 21,000 independent protein structures, and incubated/invested in 67 biotech firms. About BioMap BioMap is China's first biocomputing-driven biotech firm, led as chairman by Baidu CEO Robin Li and co-founder and CEO by Baidu Ventures' former CEO Liu Wei. BioMap was established during a period of growth in biological data. Our goal is to use AI and data to significantly improve the lives of patients. BioMap, positioned as a data-driven company, is speeding the R&D phase of early screening/diagnosis, drug discovery, and other precision medicine products by leveraging high-performance biocomputing and AI capabilities, gaining insights from our unique and vast library of population and molecular data sets. We are concentrating our efforts on developing our internal AI engine and data collection capabilities to curate our proprietary insights for difficult diseases.

Read More

INDUSTRIAL IMPACT

Palantir and Dewpoint Therapeutics Announce Strategic Partnership

Palantir Technologies Inc. | December 21, 2021

Palantir Technologies Inc. a leading builder of operating systems for the modern enterprise, and Dewpoint Therapeutics the leading biomolecular condensates company, announced a partnership for Palantir’s Foundry platform to help power Dewpoint’s efforts to discover treatments and cures for the most challenging diseases. Palantir Foundry will help to enable researchers at Dewpoint to further their understanding of condensates biology by analyzing lab data along with other data sources, including data from the published literature and databases, to identify new compounds and therapeutic approaches. Dewpoint will also use Foundry as the primary platform for its centralized knowledge repository, helping it contextualize its experimental results and prioritize the most viable outcomes. This multi-year agreement marks one of Palantir’s most comprehensive partnerships with a biotechnology company. Palantir Foundry is designed to integrate disparate and siloed information sources to lead to data-driven analysis and decision making. It allows users to track lineage across systems, making it particularly suited for work in life sciences and the biotechnology sector, where data sources come from several unique and separate systems. At Dewpoint, Foundry will be able to work seamlessly with the existing systems in its laboratories to provide researchers with a comprehensive foundation for exploration and analysis. “We think Dewpoint is changing the way the world approaches drug design by exploring new frontiers of disease biology, requiring a game changing solution that goes beyond just cloud and infrastructure to drive their R&D and scale with their vision as they grow. We are proud to partner with Dewpoint and share their passion of working on one of the most exciting translational medicine approaches of our time.” Lalarukh Haris Shaikh, Palantir’s Head of Biotech Foundry will help researchers make decisions around compound and target viability and streamline experiments and automate analysis by creating a digital twin of the research environment. One concrete example of Foundry’s use at Dewpoint Therapeutics is the expansion of the data foundation to include advanced genetic analysis for disease association and correlation with condensate content, empowering future discoveries. “Key to our approach has been creating a seamless connection between our wet-lab and dry-lab capabilities, with machine learning and AI at the center. Foundry has provided us with a solid foundation for us to fully connect and operationalize our entire lab to enterprise and enable the discovery and development of new drugs,” said Dewpoint CEO Ameet Nathwani. About Biomolecular Condensates Biomolecular condensates, formed through a process called phase separation, are membraneless droplets inside cells that facilitate molecular interactions and help cells perform vital functions. Condensates have been shown to play a critical role in key biological processes and in serious, intractable diseases across areas including neurodegeneration, cancer, inflammation, infectious disease, metabolic disease, and rare genetic disorders. The first condensates were observed more than 100 years ago. It is only in the last dozen years, though, that scientists—including Dewpoint founders Tony Hyman of the Max Planck Institute in Dresden and Rick Young of the Whitehead Institute—have begun to understand the dynamic nature and function of condensates. Dewpoint develops drugs that exploit this biology. About Dewpoint Therapeutics Dewpoint Therapeutics is the first company to apply the emerging understanding of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, infectious disease, and metabolic disease. Dewpoint scientists work in Boston, Dresden, and Berlin to translate condensate biology into treatments for the toughest diseases. About Palantir Technologies Inc. Palantir Technologies Inc. builds and deploys operating systems for the modern enterprise.

Read More