Pros and cons of genetic scissors

Phys.org | September 17, 2019

Crispr technology has greatly facilitated gene editing. Associate Professor Thorsten Müller from Ruhr-Universität Bochum and Dr. Hassan Bukhari from Harvard Medical School discuss its pros and cons in a review article in the journal Trends in Cell Biology. They believe Crispr technology has future potential primarily if it can be rendered usable in the field of stem cell research. In order to analyze the effects of genes or gene products, they used to be artificially over-activated. "Thus, they would occur up to 1,000 times more frequently than in nature," says Thorsten Müller. "The cell was flooded with gene products, the proteins, which can falsify function analysis." The Crispr method eliminates this difficulty. It can be used to implant blueprints of fluorescent proteins in cells and to position them behind a specific gene. "This has enabled us to monitor for the first time a protein's function live under natural conditions—rather than after 1,000-fold overproduction," explains the biochemist.

Spotlight

Catalysis is a powerful technology with vast potential to help address global challenges. It will play a crucial role in efforts to improve energy efficiency, reduce greenhouse gas emissions, feed a growing population, and improve health and living standards. Given its important benefits, support for catalysis should be a priority for governments, industry, and researchers.

Spotlight

Catalysis is a powerful technology with vast potential to help address global challenges. It will play a crucial role in efforts to improve energy efficiency, reduce greenhouse gas emissions, feed a growing population, and improve health and living standards. Given its important benefits, support for catalysis should be a priority for governments, industry, and researchers.

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TeselaGen Biotechnology Announced the Launch of a New Protein Optimization Toolkit for Automated Biotherapeutic Drug Design and Development

TeselaGen Biotechnology | May 21, 2021

TeselaGen Biotechnology today announced the launch of a new protein optimization toolkit for biotherapeutic drug design and development, introducing significant enhancements to the company’s flagship TeselaGen® OS to form designing and developing pharmaceuticals and biotherapeutics faster and fewer expensive. The new capabilities, easily accessible via the cloud-based platform, simplify the planning of highly complex combinatorial protein libraries and support AI models for optimizing new peptides and proteins. New application programming interfaces (APIs) and integration tools have also been extended to further enhance users’ access to the new capabilities. TeselaGen integrates the facility of AI with one end-to-end platform for design, construction, data gathering, and analysis of bioproduct performance, from pharmaceuticals to food and fabrics, significantly accelerating time to plug and reducing costs. The platform’s DESIGN, BUILD, TEST, and find out modules enable researchers to effectively collaborate across an organization's development pipeline to style and build experiments, standardize and share data, and learn and preserve project results by embedding them during a machine learning model. TeselaGen’s DESIGN is an intuitive, user-interface-driven module that permits scientists to style highly complex combinatorial libraries. With this new release, the planning now supports aminoalkanoic acid parts which will be efficiently mapped to DNA. TeselaGen can then automatically generate biology protocols for efficiently synthesizing and assembling the corresponding DNA libraries. TeselaGen’s DISCOVER now supports AI models which will recommend new peptides and proteins supported by the training of supervised and unsupervised learning models. The platform also supports the modeling of unnatural amino acids and multicriteria optimization of proteins. R&D groups can utilize the TeselaGen OS to hurry the invention process. Datasets are uploaded and arranged within the platform and immediately useful for model building within TeselaGen’s DISCOVER module. TeselaGen has demonstrated that it can increase the planning and build speed of biological products and reduce the prices related to research & development by an order of magnitude. Current partnering companies are using the new capabilities for designing antibodies and optimizing their binding affinity, titer, specific productivity, immunogenicity, or other phenotypic variables of interest. Researchers also are looking to TeselaGen for rapidly engineering new vaccines - using methods like virus-like particles (VLPs), DNA, and RNA vaccines - opening the door to attacking rapidly mutating RNA and retroviruses like influenza, HCV, HIV, or coronaviruses. About TeselaGen Biotechnology TeselaGen Biotechnology has developed the primary artificial intelligence-enabled OS for biotechnology, enabling the event and commercialization of high-performance bioproducts – from pharmaceuticals to food to fabrics – faster and easier than ever. TeselaGen® connects biologists, lab technicians, and bioinformaticians so that they will collaboratively design and build experiments, organize and standardize data then test and continually learn from the info. TeselaGen has been deployed by Fortune 50 companies and emerging innovators in biopharmaceuticals, agriculture, and specialty chemicals. the corporate is privately held and based in San Francisco, California.

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Westlake Village BioPartners Launches Two New Funds Totaling $500 Million to Build and Invest in Promising Life Sciences Companies

Westlake Village BioPartners | December 15, 2020

Westlake Village BioPartners today announced the launch of two new funds totaling $500 million to build and put resources into promising life sciences organizations with transformative therapeutic technologies. The first fund, known as Opportunity 1, is $70 million and permits Westlake to contribute extra Series B or later-round capital into promising organizations they incubated or invested into with their original fund, Westlake BioPartners 1 (WBP1). One example is a beginning phase biotechnology organization zeroed in on creating accuracy medicines for genetically characterized neurological and immunological illnesses. The second fund, Westlake Village BioPartners 2 Fund (WBP2), is $430 million and will focus in on hatching and putting resources into approximately 12 Series A new businesses or co-lead Series A rounds with different financial specialists, and will likewise consider additional Series B or later-round investments in the most encouraging of these companies.

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INDUSTRIAL IMPACT

ShouTi Introduces Basecamp Bio as a Wholly Owned Subsidiary to Expand Pipeline and Partnerships

ShouTi Inc | February 18, 2022

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