TeselaGen Biotechnology | May 21, 2021
TeselaGen Biotechnology today announced the launch of a new protein optimization toolkit for biotherapeutic drug design and development, introducing significant enhancements to the company’s flagship TeselaGen® OS to form designing and developing pharmaceuticals and biotherapeutics faster and fewer expensive. The new capabilities, easily accessible via the cloud-based platform, simplify the planning of highly complex combinatorial protein libraries and support AI models for optimizing new peptides and proteins. New application programming interfaces (APIs) and integration tools have also been extended to further enhance users’ access to the new capabilities.
TeselaGen integrates the facility of AI with one end-to-end platform for design, construction, data gathering, and analysis of bioproduct performance, from pharmaceuticals to food and fabrics, significantly accelerating time to plug and reducing costs. The platform’s DESIGN, BUILD, TEST, and find out modules enable researchers to effectively collaborate across an organization's development pipeline to style and build experiments, standardize and share data, and learn and preserve project results by embedding them during a machine learning model.
TeselaGen’s DESIGN is an intuitive, user-interface-driven module that permits scientists to style highly complex combinatorial libraries. With this new release, the planning now supports aminoalkanoic acid parts which will be efficiently mapped to DNA. TeselaGen can then automatically generate biology protocols for efficiently synthesizing and assembling the corresponding DNA libraries.
TeselaGen’s DISCOVER now supports AI models which will recommend new peptides and proteins supported by the training of supervised and unsupervised learning models. The platform also supports the modeling of unnatural amino acids and multicriteria optimization of proteins. R&D groups can utilize the TeselaGen OS to hurry the invention process. Datasets are uploaded and arranged within the platform and immediately useful for model building within TeselaGen’s DISCOVER module.
TeselaGen has demonstrated that it can increase the planning and build speed of biological products and reduce the prices related to research & development by an order of magnitude. Current partnering companies are using the new capabilities for designing antibodies and optimizing their binding affinity, titer, specific productivity, immunogenicity, or other phenotypic variables of interest. Researchers also are looking to TeselaGen for rapidly engineering new vaccines - using methods like virus-like particles (VLPs), DNA, and RNA vaccines - opening the door to attacking rapidly mutating RNA and retroviruses like influenza, HCV, HIV, or coronaviruses.
About TeselaGen Biotechnology
TeselaGen Biotechnology has developed the primary artificial intelligence-enabled OS for biotechnology, enabling the event and commercialization of high-performance bioproducts – from pharmaceuticals to food to fabrics – faster and easier than ever. TeselaGen® connects biologists, lab technicians, and bioinformaticians so that they will collaboratively design and build experiments, organize and standardize data then test and continually learn from the info. TeselaGen has been deployed by Fortune 50 companies and emerging innovators in biopharmaceuticals, agriculture, and specialty chemicals. the corporate is privately held and based in San Francisco, California.
Westlake Village BioPartners | December 15, 2020
Westlake Village BioPartners today announced the launch of two new funds totaling $500 million to build and put resources into promising life sciences organizations with transformative therapeutic technologies.
The first fund, known as Opportunity 1, is $70 million and permits Westlake to contribute extra Series B or later-round capital into promising organizations they incubated or invested into with their original fund, Westlake BioPartners 1 (WBP1). One example is a beginning phase biotechnology organization zeroed in on creating accuracy medicines for genetically characterized neurological and immunological illnesses.
The second fund, Westlake Village BioPartners 2 Fund (WBP2), is $430 million and will focus in on hatching and putting resources into approximately 12 Series A new businesses or co-lead Series A rounds with different financial specialists, and will likewise consider additional Series B or later-round investments in the most encouraging of these companies.
ShouTi Inc | February 18, 2022
ShouTi Inc., a clinical-stage global biopharmaceutical company developing novel oral therapeutics to treat a wide range of chronic diseases, today introduced Basecamp Bio, a wholly owned subsidiary dedicated to fueling ShouTi’s pipeline and pursuing drug discovery partnerships.
Basecamp Bio integrates unique insights, skills, technological know-how and experience to navigate the complex challenges of membrane protein structure-based drug discovery. Its mission is to prosecute the most challenging structure-based drug discovery targets, including G-protein coupled receptors (GPCRs), and deliver discovery assets to ShouTi’s development pipeline. In addition, Basecamp Bio will explore selective partnerships to tackle high value targets pursued by the biopharmaceutical industry.
Basecamp Bio is led by Yingli Ma, Ph.D., President, who brings close to 15 years of research, technology, and drug discovery experience including her previous role as general manager of Amgen Shanghai Research Center. Dr. Ma led Amgen’s global structural biology and drug discovery programs in cardiometabolic and inflammatory diseases.
“By bringing together our deep expertise in structure-based drug design with leading drug discovery technologies, we aim to create orally-available small molecule medicines against some of the most complex targets including those validated by biologics,” said Dr. Ma. “With all of these breakthrough technologies under one roof, and access to the Shanghai biotech contract research organization ecosystem as a resource, Basecamp Bio has the ability to greatly accelerate the discovery of assets with best-in-class potential.”
Basecamp Bio’s technology leverages the power of cryo-electron microscopy, machine learning and X-ray crystallography, as the basis for its molecular designs. The company employs state-of-the-art small molecule hit identification, including DNA encoded library technology and affinity mass spectrometry selections for membrane proteins. This is integrated with cutting-edge computational chemistry and medicinal chemistry along with a matrix of pharmacological assay platforms. ShouTi’s exceptional experience with cell surface receptor signaling and pharmacology will further enable Basecamp Bio to achieve its goal of designing medicines with optimal pharmaceutical properties to address patient needs.
“Given the broad potential of the platform and our team’s deep expertise with challenging drug targets, we are excited to deploy Basecamp Bio to both advance our own pipeline and enable early-stage drug discovery partnerships to extend the reach of our leading-edge science,”
Melita Sun Jung, Chief Business Officer, ShouTi
ShouTi is a clinical stage global biopharmaceutical company aiming to develop and deliver novel oral therapeutics to treat a wide range of chronic diseases with unmet medical needs. The company’s cutting-edge technology platform leverages structure-based drug discovery and computational chemistry expertise and enables ShouTi to develop oral small molecule therapeutics for the treatment of various diseases, including those in the metabolic, cardiovascular, and pulmonary therapeutic areas. By leveraging ShouTi’s world-class GPCR know-how, the company aims to design differentiated small molecule therapies to overcome the limitations of biologics and peptide therapies targeting this family of receptors.