Nucleus Biologics Unveils World's First Online Portal for Instantaneous Custom cGMP Cell Culture Media Configuration

Nucleus Biologics | May 27, 2020

Nucleus Biologics, a leader in precision cell culture, today announced the availability of NB-Lux™, an online configuration and ordering platform for cell culture media. Designed for developers of cell therapies, NB-Lux™ speeds formulation development by providing real time pricing for cGMP grade media in lot sizes from two liters to 2000 liters. Media is a critical component in the production of cell therapies. During development, companies iteratively test multiple formulations to identify an optimal medium for cGMP manufacturing. Some therapy developers utilize proprietary, off-the-shelf formulations for perceived streamlining in regulatory processes. However, unknown formulations are difficult to tailor to specific therapies, are not part of a therapy company's intellectual property portfolio and are vulnerable to supply chain issues due to sole sourcing. Equally undesirable, custom media currently takes up to six months to manufacture after it has been formulated. "Our mission is to speed the time from discovery to cure. We listened to the frustration of our cell therapy customers and reimagined the cell culture media configuration and ordering experience. No longer must a scientist guess what to add to proprietary, sole sourced medias or wait almost half a year to receive custom media," said David Sheehan, Founder, President and CEO of Nucleus Biologics. "NB-Lux™, a first-of-its-kind portal, empowers a scientist to create their own formulas, get real time quotes, and, in some situations, have cGMP media manufactured in as little as 9 weeks. This is the first step in our plan to reshape the media market. My sense is the COVID-19 pandemic has punctuated the need for the scientific community and industry to create new paradigms that expedite delivery of proven therapies." Nucleus Biologics developed the patent-pending NB-Lux™ to provide real time quotes for cGMP cell culture media. Users can input and manipulate different formulations online, receive real time pricing, and track order progress. NB-Lux™ is powered by one of the largest repositories of over 400 publicly available formulations. Users can optimize each individual chemical component, testing requirements, and packaging. By customizing a media to the unique critical attributes of each therapy, developers can take control of formulations, rapidly progress from small- to large-scale production, and move therapies to the clinic faster.

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No one benefits from research if it is not applied; results are of no use if placed in a drawer! Matís has always aimed to put research results in good use and focuses on applied science based on the industry need.

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No one benefits from research if it is not applied; results are of no use if placed in a drawer! Matís has always aimed to put research results in good use and focuses on applied science based on the industry need.

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INDUSTRIAL IMPACT

iNtRON Confirms Efficacy of CDL200 Against CDI Clinical Isolates

iNtRON Biotechnology | July 12, 2022

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INDUSTRIAL IMPACT

Orion Biotechnology and Peptilogics Enter Strategic Research Collaboration to Enable AI-Driven Drug Discovery Against Undrugged GPCR Target

Orion Biotechnology | July 15, 2022

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DIAGNOSTICS

GRAIL Announces Strategic Collaboration With AstraZeneca to Develop Companion Diagnostic Tests to Enable the Treatment of Early-Stage Cancer

GRAIL | June 06, 2022

GRAIL, LLC, a healthcare company whose mission is to detect cancer early when it can be cured, today announced a broad strategic collaboration with AstraZeneca (LSE/STO/Nasdaq: AZN) to develop and commercialize companion diagnostic (CDx) assays for use with AstraZeneca’s therapies. The collaboration will initially focus on developing companion diagnostic tests to identify patients with high-risk, early-stage disease, with plans to embark on numerous studies across multiple indications over the next several years. The parties are additionally planning to use GRAIL’s technology to enable recruitment of patients with early-stage cancer for AstraZeneca’s clinical studies. GRAIL has developed a novel approach to detect cancer signals in blood, regardless of whether or not the patient has clinical symptoms. We are excited to embark on this work with AstraZeneca to transform cancer outcomes through a broad, strategic collaboration, Through our collaboration, we hope to provide critical information to improve the identification of patients who may be eligible for clinical trials and change clinical paradigms for the treatment of early-stage cancers." Sir Harpal Kumar, President, Biopharma Business and Europe at GRAIL. Across the projects within this collaboration, GRAIL will use its methylation platform to perform testing for patients enrolled in AstraZeneca’s clinical trials. GRAIL will seek regulatory approval in key markets for the liquid biopsy companion diagnostics. Identifying and treating cancer early is at the heart of this strategic collaboration. Combining GRAIL’s innovative blood-based methylation profiling platform with AstraZeneca’s leadership in Oncology, we hope to accelerate the adoption of circulating tumor DNA across clinical trials and make our cancer medicines available at an earlier stage of disease when there is greater potential to transform patient outcomes, and even cure.” Susan Galbraith, Executive Vice President of Oncology R&D, AstraZeneca. GRAIL is developing its proprietary methylation platform for use in multiple post-diagnostic settings to identify patients at high risk of future cancer recurrence, detect the presence or absence of residual disease, and to inform treatment decisions, including identifying patients with cancer who may be eligible for neoadjuvant or adjuvant therapy. GRAIL’s technology platform is designed to optimize circulating tumor DNA testing to enable detection of early stage disease and minimal residual disease (MRD). About GRAIL GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC, is a subsidiary of Illumina, Inc. (NASDAQ:ILMN) currently held separate from Illumina Inc. under the terms of the Interim Measures Order of the European Commission dated 29 October 2021.

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