Novel treatments offer new hope for patients with autoimmune disease

Medical Xpress | March 04, 2019

Autoimmune diseases, including type 1 diabetes and multiple sclerosis, arise when the body's immune cells attack itself. Current treatments eliminate these misfunctioning immune cells, but also destroy normal, protective immune cells, leaving patients susceptible to immune deficiency and opportunistic infections. Researchers at the University of Utah Health have developed a new approach that targets the misfunctioning immune cells while leaving normal immune cells in place. The results of their study are available online in the March 4 issue of Nature Biomedical Engineering. "We are really taking treatment for the autoimmune disease in a new direction," begins Mingnan Chen, Ph.D., assistant professor in Pharmaceutical Chemistry at U of U Health. "This is the first time anyone has looked at the programmed cell death protein (PD-1) cells as a target to develop therapeutics for autoimmune disease." The team tested the treatment in a mouse model that mimics type 1 diabetes. They found the treatment delayed the onset of diabetes in mice (29 weeks old compared to 19 weeks old for control-treated mice). In addition, the treatment was also applied to a mouse multiple sclerosis model (experimental autoimmune encephalomyelitis). Not only did the treatment halt the progression of paralysis in the six mice in this model, but these mice also regained the ability to walk. The team monitored the mice for 25 days after treatment and found the paralysis did not return.

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Good-quality RNA is crucial to the success of many downstream applications, including qPCR, microarray analysis, and RNA sequencing. Agilent automated

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Good-quality RNA is crucial to the success of many downstream applications, including qPCR, microarray analysis, and RNA sequencing. Agilent automated

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Bicycle Therapeutics | September 08, 2022

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Ordaōs and NonExomics | September 29, 2022

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