New potential therapeutic target for pancreatic cancer discovered

Medical Xpress | March 27, 2019

Cancer cells demand enormous amounts of molecular "food" to survive and grow, and a study published March 27 online in Nature by researchers at The University of Texas MD Anderson Cancer Center may have identified a new approach to starve the cells of one of the most common and deadly cancers, pancreatic cancer. A state-of-the-art approach, developed by the team of the senior author, Giulio Draetta, M.D., Ph.D., chief scientific officer and professor of genomic medicine, was used to track how pancreatic cancer cells rearrange proteins on their surface. This uncovered a protein, called syndecan-1 (SDC1), that moves to the cell surface in response to signals from mutant KRAS, a protein known to be present in more than 90 percent of pancreatic ductal adenocarcinomas. The study further explained that the positioning of SDC1 on the cell surface is essential for pancreatic cancer cells to upregulate macropinocytosis, a mechanism cells use to scavenge resources from their environment to turn into energy or to prepare them to divide.

Spotlight

Every day, billions of sharp, invisible fibers are making their way out to our oceans and air, and into our water, wine, beer, and cells. It’s no secret that too many of the plastic products we use end up in the ocean. But you might not be aware of one major source of that pollution: our clothes.

Spotlight

Every day, billions of sharp, invisible fibers are making their way out to our oceans and air, and into our water, wine, beer, and cells. It’s no secret that too many of the plastic products we use end up in the ocean. But you might not be aware of one major source of that pollution: our clothes.

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Controlant now Providing Monitoring and Supply Chain Visibility for Pfizer-BioNTech COVID-19 Vaccine's Global Distribution

Controlant | December 16, 2020

Controlant, an leader in real-time supply chain monitoring and perceivability technologies for vigorously controlled ventures, for example, pharmaceuticals and life sciences and food and drink areas, today reported it is giving observing and Supply Chain Visibility administrations to Pfizer, comparable to the conveyance of Pfizer's mRNA-based Pfizer-BioNTech COVID-19 vaccine's worldwide circulation. In addition to the visibility and monitoring arrangements that Controlant is providing to Pfizer to mRNA-based Pfizer-BioNTech COVID-19 vaccine distribution supply chain, the organization is likewise working straightforwardly with the U.S. Government and wellbeing authorities, for example, the Center for Disease Control (CDC), U.S. Division of Health and Human Services (HHS), and stakeholders in Operation Warp Speed, to give nearby observing at U.S. Government-preferred designated vaccination areas to help consistently guarantee coherence during hand-off, actionable communication, and visibility, all through the entirety of the U.S. supply chain journey of the vaccines.

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CELL AND GENE THERAPY

Evonetix Demonstrates Novel Enzymatic DNA Synthesis Method

EVONETIX LTD | March 02, 2022

EVONETIX LTD the synthetic biology company bringing semiconductor technology to DNA synthesis, announced it has achieved enzymatic DNA synthesis capability with its proprietary, thermally controlled synthesis chemistry. The culmination of a three-year development program, supported by Innovate UK and in collaboration with Durham University, the results demonstrate that Evonetix’s unique, semiconductor array-based platform is compatible with both chemical and enzymatic DNA synthesis, enabling the production of scarless DNA sequences that are directly compatible with downstream processing. Synthetic biology is expected to impact many industries, but the production of high-fidelity DNA at scale, without the need for post-synthesis error correction, has remained a challenge. Evonetix‘s unique approach re-engineers traditional phosphoramidite synthesis chemistry to use thermal, rather than acidic, control of deprotection reactions. This approach enables parallel synthesis of thousands of sequences on a single chip. The research was directed by Dr Raquel Sanches-Kuiper, VP of Technology at Evonetix, whose enzyme engineering team has focussed on the development of enzymes that can incorporate Evonetix modified nucleotides efficiently. The programme was completed in collaboration with Dr David Hodgson, Associate Professor of Chemistry at Durham University, whose group was involved in developing the modified nucleotides for enzymatic synthesis in Evonetix silicon arrays. “We have, for the first time, demonstrated thermally controlled enzymatic DNA synthesis. Our approach brings together thermally controlled synthesis and error detection, allowing for high-throughput assembly of high-fidelity gene-length DNA at scale. Our synthesis platform can now be used with both enzymatic and chemical synthesis, allowing us to smoothly integrate our enzymatic approach as this technology develops. Our unique, on-chip, synthesis and error correction platform will overcome many of the existing challenges in current approaches to de novo gene synthesis.” Dr Raquel Sanches-Kuiper, VP of Technology at Evonetix Dr David Hodgson, Associate Professor of Chemistry at Durham University, added: “We have been able to combine our world leading expertise in nucleotide chemistry with the novel Evonetix approach for enzymatic DNA synthesis, enabling cleaner, simpler synthesis reactions that will ultimately allow for scaled production of high-quality synthetic DNA with revolutionary applications across industry and research.” Simon Rowland, Innovate UK, commented “Engineering Biology was identified in the 2021 UK Innovation Strategy as one of the key technologies that will deliver future economic success in the UK. The rapidly growing synthetic biology market is estimated to reach $40 billion by the mid-2020s. Innovate UK supports businesses and research institutions to drive business investment into R&D and is proud to have supported Evonetix and the development of this game changing innovation in DNA synthesis.”

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MEDICAL

Gator Bio Signs Exclusive Distribution Agreement with I&L Biosystems

Gator Bio, Inc. | June 02, 2022

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