Neuropore Therapies Receives $500,000 Grant from The ALS Association

BioSpace | February 17, 2020

Neuropore Therapies, Inc., a biopharmaceutical company discovering and developing novel therapeutics for the treatment of neurodegenerative disorders, announced today that it has been awarded a $500,000 grant from The ALS Association to support the preclinical evaluation and development of its leading Toll-Like Receptor 2 (TLR2) antagonist NPT1220-312 for the treatment of amyotrophic lateral sclerosis. The grant has been made through the Association’s Lawrence and Isabel Barnett Drug Development Program.

Spotlight

The CleanSeam+ Pass-Through chamber isolates the interlock in a double-wall housing, providing the optimal transfer chamber for the broadest range of critical applications, including cleanliness requirements to ISO 4 and bio/pharmaceutical operations that require frequent cleaning and sterilization. Flush-mount design eliminates surfaces that collect contaminants, and double-wall constructions isolates interlock outside the transfer chamber. These features make this unit ideal for critical applications that require ultra-smooth, easy-clean surfaces.

Spotlight

The CleanSeam+ Pass-Through chamber isolates the interlock in a double-wall housing, providing the optimal transfer chamber for the broadest range of critical applications, including cleanliness requirements to ISO 4 and bio/pharmaceutical operations that require frequent cleaning and sterilization. Flush-mount design eliminates surfaces that collect contaminants, and double-wall constructions isolates interlock outside the transfer chamber. These features make this unit ideal for critical applications that require ultra-smooth, easy-clean surfaces.

Related News

INDUSTRIAL IMPACT

Orion Biotechnology and Peptilogics Enter Strategic Research Collaboration to Enable AI-Driven Drug Discovery Against Undrugged GPCR Target

Orion Biotechnology | July 15, 2022

Orion Biotechnology Canada Ltd, a drug discovery company targeting previously undruggable G Protein-Coupled Receptors and Peptilogics, a biotech company engineering peptide therapeutics by combining computation and biology to improve the treatment landscape for patients with life-threatening diseases, announced today that they have entered a research and development collaboration to leverage AI for drug discovery against an undrugged GPCR target. The collaboration will combine the capabilities of Peptilogics’ AI platform (NautilusTM) with Orion Biotechnology’s proprietary drug discovery platform. The companies will leverage expertise in peptide design and engineering to drive drug discovery against an undrugged peptidergic GPCR linked to highly prevalent, life-threatening diseases. Peptilogics’ Nautilus™ platform enables in silico predictive peptide design across diverse targets to efficiently access new functional chemical space and custom-design therapeutics. Additionally, Peptilogics’ supercomputer accelerates model development, prediction and evaluation of peptide sequences to produce higher quality hits with greater chance of success. Synergistically, Orion Biotechnology’s platform explores receptor-ligand shape space using proprietary multiplex synthesis technology to generate precision-engineered peptides with enhanced potency and tailored signaling activity. Orion’s platform generates data matrices for AI-assisted lead optimization, offering one of the fastest drug discovery and development solutions to target peptidergic GPCRs. On the announcement of this collaboration, Dr. Oliver Hartley, VP Drug Discovery at Orion Biotechnology, commented, “We are pleased to be partnering with Peptilogics to push the boundaries of receptor pharmacology and AI computing to accelerate innovation for improved patient outcomes. An AI-driven paradigm shift is happening in drug discovery, and Orion is pleased to be at the forefront of applying AI to the highly valuable space around GPCRs. The ideal fit between Orion’s platform and unique knowledge of receptor-ligand interactions with Peptilogics’ machine learning models will position us to make AI-driven GPCR drug discovery a reality.” “Using Peptilogics’ Nautilus™ platform, we combine proprietary deep generative models, predictive models and biophysical simulation to design multiparameter-optimized peptides that have the potential to address historically challenging and novel drug targets. Our AI algorithms enable efficient navigation of the vast peptide design space, allowing us to uncover molecules that may not be discovered through traditional screening. We are excited to partner with Orion Biotechnology for their deep GPCR expertise. By combining the strengths of Peptilogics’ Nautilus™ AI-driven peptide design platform and Orion’s GPCR platform, we aim to reduce the risk, time and cost for drug design.” Nicholas Nystrom, Ph.D., Chief Technology Officer of Peptilogics About Orion Biotechnology Orion Biotechnology Canada Ltd. is unlocking the therapeutic potential of previously undruggable G Protein-Coupled Receptors (GPCRs). Orion’s world-renowned experts in GPCR pharmacology and peptide/protein engineering leverage Orion’s proprietary drug discovery platform to rapidly and efficiently advance a diversified portfolio of precision engineered GPCR-targeted therapeutic candidates for the treatment of cancer and other serious diseases. About Peptilogics Peptilogics engineers peptide therapeutic candidates to radically improve the treatment landscape for patients with life-threatening diseases. Through biological and pharmaceutical expertise, novel artificial intelligence algorithms, and purpose-built super-computing, Peptilogics is advancing an extensive therapeutic pipeline and accelerating discovery efforts at a pace and scale that was previously impossible. Peptilogics is backed by visionary investors in life science and technology including Peter Thiel, Presight Capital, Founders Fund, CARB-X, and Cystic Fibrosis Foundation.

Read More

MEDICAL

Fauna Bio's Comparative Genomics Approach Finds New Compounds for Heart and Lung Diseases

Fauna | June 15, 2022

Fauna Bio, a biotechnology company pioneering the fields of comparative, computational and translational genomics, is celebrating its fourth birthday this month with the release of Centaur, a knowledge graph that is the first of its kind to visualize the intersection between animal gene expression data and human diseases in one comprehensive map. With Centaur, Fauna Bio is able to more rapidly identify human disease indications and targets to generate new therapeutic solutions for some of the most serious human diseases. Orca is another new update to the Convergence platform, and enables direct comparison of gene expression signatures from naturally disease-resistant species with those from humans. Convergence now leverages genomic analyses across 452 mammal species (65 of which are hibernators), an 86 percent increase from two years ago. Much of the company's focus is cardiac and pulmonary diseases, where current treatments mainly focus on symptom management rather than treating the underlying condition. Faun1003, a compound discovered through LEO (Fauna Bio's drug prediction module), is being investigated for use in lung injury and pulmonary hypertension. While uniquely differentiated, retrospective analyses of similar compounds show a survival advantage in critical care settings for patients with lung injury that receive this drug, providing additional human support for the target of Faun1003. Fauna Bio's first neuronal program, Faun264G, looks to improve the survival of human neurons deprived of glucose. A pilot study found knockdown of 264G in-vivo impairs the ability of 13-lined ground squirrels to enter torpor, validating its function. Fauna will continue with expanded in-vivo experiments to understand its role in controlling metabolism this summer. Fauna Bio has also initiated a new discovery program in inflammatory bowel disease, seeking targets to improve epithelial barrier function and reduce immune cell migration. Forty-five percent of compounds predicted for use in IBD by LEO have already been investigated, suggesting strong enrichment for IBD targets. The company has also completed brain cortex and kidney sequencing, with target predictions coming soon. These updates build on the company's momentum since raising $9M in funding last year. Since then, Fauna has expanded partnerships with leading academic institutions, including the University of Wisconsin-Oshkosh and Monash University in Australia. Both collaborations focus on studying genes from the 13-lined ground squirrel that allow for survival during hibernation under extreme conditions. Monash University will assist in additional pre-clinical testing of Fauna compounds, while UW-O supports the existing colony, additional tissue collections, and in-vivo experiments. Through a new partnership with the University of Nevada - Las Vegas, Fauna will add genes from tenrecs, a second hibernating species, to Fauna Bio's proprietary biobank. We continue to see how the power of comparative genomics, and looking outside of our own species, is like building a stronger magnet to help us find that elusive needle in the haystack. By introducing a small amount of the right data and applying it in the right way, we can more quickly identify the real opportunities to make a difference for people suffering from diseases with unmet needs, We've had incredible support from the National Human Genomics Research Institute, the National Institute of Health, our investors, and advisors to continue educating and bringing these programs closer to finding real therapeutic solutions for many of the worst human diseases." Ashley Zehnder, Ph.D., D.V.M, CEO of Fauna Bio. About Fauna Bio Fauna Bio is an end-to-end target and drug discovery platform company and a pioneer in computational, comparative and translational genomics. Fauna Bio is mining the shared genetics between mammals and humans to pinpoint specific genes and pathways that result in disease resistance to some of the most common and deadly human diseases. With a proprietary biobank that includes thousands of tissue samples across multiple species and time points, unparalleled data curation, comparative genomics, machine learning-based target predictions and compound predictions, the Fauna Bio platform identifies extraordinary genes which are highly conserved across species and predicts small molecules that replicate disease resistance to jumpstart human drug development.

Read More

MEDICAL

Gator Bio Signs Exclusive Distribution Agreement with I&L Biosystems

Gator Bio, Inc. | June 02, 2022

Gator Bio, the next gen Biolayer Interferometry solutions company, has signed an agreement with I&L Biosystems GmbH, a distributor of innovative biomedical technology and products. The agreement will allow Gator Bio to expand rapidly its product offerings into the European Union, a key region for Gator's growth strategy as it begins its global reach. I&L Biosystems has a history of bringing new and innovative technologies into market — as evidenced by its previous success in commercializing e.g., various multi-analyzer, protein purification devices, SPR instruments, and bioreactors, etc. We look forward to working with the I&L team to bring the Gator platform to users throughout the region, helping meet the demand for therapeutics development and manufacturing." Dr. Hong Tan, CEO of Gator Bio. Gator BLI platform and a range of innovative biosensors are an important addition to I&L's portfolio of protein characterization products, and we are very excited about the possibilities the Gator shall give our customers in characterizing antibodies, AAVs and small molecule drugs, Access to this next gen technology is key to the continued enablement of our biopharma and academia research customers across our geographies. We are very excited about helping research and manufacturing community with the novel applications in gene therapy, immune therapy and lipid nano particle development." Mr. Alexander M. Beljaars, CEO of I&L Biosystems GmbH. The latest partnership of two companies builds on Gator Bio's commitment to providing high-quality BLI platforms globally, recently demonstrated through a strategic partnership with BMS Korea (Bio Medical Sciences) to provide sales and services to biotherapeutics and gene therapy companies in Republic of Korea. About Gator Bio, Inc. Gator Bio is a life sciences company providing bioanalytical systems to accelerate the development of therapeutics and diagnostics. Gator Bio along with its sister company ET Healthcare are part of Access Medical Systems. The Gator instruments and biosensors enable real-time analysis of biomolecular interactions providing information on affinity, kinetics, concentration and epitope binning, etc. Most importantly, Gator Bio's analytical capabilities enable better and faster characterization of drug candidates, thus providing greater value in drug development applications where existing methods have limitations in throughput, performance, and cost. The company is headquartered in Palo Alto, California with facilities in Shanghai and Suzhou, China. About I&L Biosystems I&L Biosystems is a leading distributor of innovative scientific products with the headquarter in Königswinter, Germany. The company was founded in 1991 and has been growing steadily ever since. The focus of I&L is on sales and distribution of high-quality laboratory equipment to customers and researchers in the microbiology, cell biology and biotechnology markets in almost all European countries. High quality of the products, competent advice and fast service are the basis for a long-lasting relationship with our customers and partners in industry, research and development. More than 120 employees ensure that our customers throughout Europe receive excellent support for technical or application-related questions.

Read More