Nanoparticles and Cancer Drug Combined to Target Inflammatory Neutrophils

GEN | November 07, 2019

Researchers at Washington State University (WSU) have developed a novel, patent-pending treatment for diseases associated with inflammatory responses, including sepsis, stroke, rheumatoid arthritis, acute lung injury, and atherosclerosis. The new approach uses protein nanoparticles (NPs) to deliver the cell-killing drug doxorubicin (DOX) directly to the activated neutrophils that drive the exaggerated immune response involved in inflammatory diseases. Laboratory studies and tests in live mice showed that treatment using the nanoparticles specifically killed activated neutrophils without compromising the immune system, led to increased survival in a mouse model of sepsis, and prevented brain damage in a mouse model of stroke. “Scientists have started realizing that neutrophils—which were always seen as the ‘good guys’ for the key role they play in our immune system—are actually also contributing to the pathology of all kinds of diseases,” said the study’s senior author Zhenjia Wang, PhD, an associate professor in the WSU College of Pharmacy and Pharmaceutical Sciences. “Our experiment found that our doxorubicin albumin nanoparticles can decrease the lifespan of harmful neutrophils in the bloodstream. More importantly, we also found that our nanoparticles don’t inhibit the neutrophils’ function in the bone marrow.”

Spotlight

Europe continues to be a powerhouse of science and innovation. The region maintains a clear lead over China, the United States, and the rest of the world in terms of the quality and quantity of its science. For example, Europe is home to 43 of the global top 100 life-science universities, while the United States has 34. Europe is a powerhouse in scientific publishing as well, with roughly twice the output of the United States and three times that of China. Europe also leads in terms of quality, as measured by the number of citations for its publications. More than 40,000 biotech patents have been granted in Europe since 2015, although the region’s 3 percent CAGR in patent approvals between 2015 and 2019 lagged behind that of the United States (4 percent) and was a fraction of China’s (14 percent). Despite Europe’s strength in science and innovation, translation remains the biggest challenge. Translation of science into companies is stagnant. The distribution of newly funded biotechs remains unchanged across geographies over the last six years, and Europe accounts for only 25 percent of new biotechs. Future success will depend on improving the translation of research into new companies, raising more capital, and building entrepreneurial talent.

Spotlight

Europe continues to be a powerhouse of science and innovation. The region maintains a clear lead over China, the United States, and the rest of the world in terms of the quality and quantity of its science. For example, Europe is home to 43 of the global top 100 life-science universities, while the United States has 34. Europe is a powerhouse in scientific publishing as well, with roughly twice the output of the United States and three times that of China. Europe also leads in terms of quality, as measured by the number of citations for its publications. More than 40,000 biotech patents have been granted in Europe since 2015, although the region’s 3 percent CAGR in patent approvals between 2015 and 2019 lagged behind that of the United States (4 percent) and was a fraction of China’s (14 percent). Despite Europe’s strength in science and innovation, translation remains the biggest challenge. Translation of science into companies is stagnant. The distribution of newly funded biotechs remains unchanged across geographies over the last six years, and Europe accounts for only 25 percent of new biotechs. Future success will depend on improving the translation of research into new companies, raising more capital, and building entrepreneurial talent.

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AvantGen Announces Licensing of its anti-SARS-CoV-2 Antibody Clones to IGM Biosciences for COVID-19 Therapy Development

AvantGen | January 12, 2021

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Immagene and Selvita Announce Integrated Drug Discovery Cooperation

Selvita | February 07, 2022

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Oracle and Oxford Nanopore Team Up to Improve Healthcare and Speed Discovery of New Medical Breakthroughs

Oracle | September 16, 2021

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