Membrane protein function behind epilepsy discovered

Drug Target Review | August 30, 2019

Researchers have revealed the 3D structure of a membrane protein which plays a role in the development of conditions such as epilepsy and blindness. A research team has announced their unprecedented discovery of the three-dimensional (3D) structure and mechanism of a membrane protein which causes epilepsy and muscle problems. The scientists, from the Korea Brain Research Institute (KBRI), South Korea, say their findings can be used in the development of therapies to control the protein. Previous studies have shown that neurons control the delivery of electrical signals and secretion of signal transduction materials by exchanging chloride ions and hydrogen ions in the cell membrane. A transporter protein known as CLC is involved in this process so if this is affected, muscle problems, epilepsy, hearing loss and blindness can develop. The current study succeeded in identifying for the first time the structure of external glutamate residue, which plays a critical role in the ion exchange of single CLC transporter proteins.

Spotlight

The biodiversity of planet Earth is the total variability of life forms. An estimated 1.5 million extant species are believed to have been described so far, and scientists expect there to be 5 ± 3 million extant species on Earth.

Spotlight

The biodiversity of planet Earth is the total variability of life forms. An estimated 1.5 million extant species are believed to have been described so far, and scientists expect there to be 5 ± 3 million extant species on Earth.

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