Lifespan in Humans Linked to Neural Activity

GEN | October 17, 2019

Studies by scientists at the Blavatnik Institute, Harvard Medical School (HMS), have provided the first evidence that the level of activity in the human nervous system may impact on lifespan. Neural activity in the brain has previously been implicated in disorders including dementia and epilepsy, but while previous studies have suggested that parts of the nervous system can influence aging in animals, the role of neural activity in aging, especially in humans, hasn’t been well understood. The newly reported research combines data from studies in humans, mice and the nematode model organism Caenorhabditis elegans. The combined results suggest that increased neural activity in the brain is linked with shorter lifespan, while suppressing neuronal excitability extends lifespan. The degree of neuronal activity appears to be under the control of a known transcriptional repressor, REST, which the researchers suggest could represent a target for holding back the ageing process in humans. “We suggest that activation of REST and reduction of excitatory neural activity could be an approach to slowing ageing in humans,” they report in Nature.

Spotlight

The Bioeconomy refers to the sustainable production and conversion of biomass into a range of food, health, fibre and industrial products and energy. Renewable biomass encompasses any biological material (agriculture, forestry and animal-based including fish) as a product in itself or to be used as raw material.

Spotlight

The Bioeconomy refers to the sustainable production and conversion of biomass into a range of food, health, fibre and industrial products and energy. Renewable biomass encompasses any biological material (agriculture, forestry and animal-based including fish) as a product in itself or to be used as raw material.

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NiKang Therapeutics | May 31, 2021

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INDUSTRIAL IMPACT

Legend Biotech Achieves Milestone Payments in BCMA CAR-T Collaboration with Janssen

Legend Biotech Corporation | February 14, 2022

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Xylyx Bio | August 27, 2020

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