iTolerance to Collborate with LyGenesis for Joint Research

iTolerance | July 01, 2022

iTolerance, Inc., an early-stage privately held regenerative medicine company developing technology to enable organoid, tissue, and cell therapy, announced entering into a joint collaboration with LyGenesis, Inc., a clinical-stage biotechnology company with an organ regeneration technology platform. The joint collaboration is aimed at evaluating the potential of iTOL-201, a product candidate being developed combining LyGenesis' LYG-LIV-100 liver cell therapy and iTolerance's SA FasL microgel immune tolerance platform to permit the growth of ectopic livers without the requirement for immune suppression.

The joint research effort of iTolerance and LyGenesis has produced in vitro data using iTOL-201 and is now moving toward small animal proof of concept work to assess the potential of the combined technology for producing ectopic livers capable of saving the animals from fatal liver disorders without the requirement for immune suppression.

With our lead therapy now in the clinic in a Phase 2a trial in patients with End Stage Liver Disease, we have turned our attention toward a second-generation therapy capable of growing ectopic organs without the need for immune suppression. iTolerance's platform holds enormous promise in this respect and we look forward to the results from our joint proof of concept work."

Dr. Michael Hufford, Co-Founder and Chief Executive Officer of LyGenesis.

While long-term immunosuppression continues to be an obstacle for the use of cell and regenerative therapies, the research being conducted between both LyGenesis and iTolerance could allow for a major advancement in organ regeneration, As we advance our own pipeline of therapies focused on supporting pancreatic islet engraftments, I believe this synergistic collaborative research with LyGenesis has the potential to successfully combine technologies to drive significant value for both biotech companies and importantly, the patients we work to serve."

Dr. Anthony Japour, Chief Executive Officer of iTolerance.


CRISPR Therapeutics was preparing to treat patients using its gene editing tool later this year But the Biotech company is hitting a snag. Namely: The Food and Drug Administration. The FDA just put a hold on one of the first trials to test CRISPR gene-editing in humans. The trial had hoped to look at how gene-editing may affect patients with sickle cell disease. The trail was to be conducted by CRISPR Therapeutics in conjunction with Vertex Pharmaceuticals. It is on hold "pending the resolution of certain questions that will be provided by the FDA."


CRISPR Therapeutics was preparing to treat patients using its gene editing tool later this year But the Biotech company is hitting a snag. Namely: The Food and Drug Administration. The FDA just put a hold on one of the first trials to test CRISPR gene-editing in humans. The trial had hoped to look at how gene-editing may affect patients with sickle cell disease. The trail was to be conducted by CRISPR Therapeutics in conjunction with Vertex Pharmaceuticals. It is on hold "pending the resolution of certain questions that will be provided by the FDA."

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Enveric Biosciences Advances Drug Development for Mental Health Indications and Intellectual Property Portfolio

Enveric Biosciences, Inc | July 14, 2022

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