MEDICAL

GenScript Launches GMP Single-Strand and Double-Strand DNA Service for Supporting Gene and Cell Therapy Development

GenScript | May 18, 2022

Gen_Script_Launches
GenScript USA Inc., the world's leading life-science research tools and services provider, announced the availability of new GMP-grade GenExact™ single-stranded DNA (ssDNA) and GenWand™ closed-end linear double-stranded DNA (dsDNA) services. These services will enable next-generation gene and cell therapy R&D programs to advance to IND filing and clinical trials faster and more efficiently.

Today's announcement, made at the American Society of Gene & Cell Therapy (ASGCT) 25th annual meeting (booth #280), further establishes GenScript as the leading provider of non-viral homology-directed repair (HDR) template solutions for immune-cell engineering. GenScript now offers varying grades of non-viral HDR payload materials that support use cases across early discovery research, process development, and clinical studies.

CRISPR-based non-viral gene insertion methods have gained popularity among research teams with concerns about the FDA's recent draft guidance concerning the use of viruses for gene and cell therapy. Non-viral HDR templates, in combination with CRISPR technology, can accelerate cell engineering compared to traditional GMP virus-based engineering, delivering results faster than alternate techniques.

This new investment by GenScript demonstrates our commitment to non-viral delivery technology. We look forward to continuing to work with our partners and stakeholders in academia and industry to support their cell therapy R&D programs and further development of non-viral delivery platforms and workflows, We know this technology will be a more efficient and safer solution for cell engineering."

Ray Chen, PhD, president of GenScript USA Life Science Group.

GenScript's GMP ssDNA And dsDNA services enable faster CAR-T drug development:

  • GenExact™ ssDNA up to 5000nt in length, 100mg/batch production scale
  • GenWand™ closed-end, linear dsDNA up to 10,000nt in length, gram level/batch production scale

GenScript has been collaborating with several academic and industry partners in the development of CRISPR non-viral gene insertion. Recently, Dr. Alex Marson's lab at UCSF published a paper demonstrating how CRISPR RNP technology can both knock out endogenous T-cell receptors and integrate replacement anti-cancer receptors.

The UCSF team has been using GenScript's latest single-strand DNA to improve non-viral gene knock-in efficiency. Working in collaboration with GenScript, the team engineered modifications to the DNA payload to promote co-localization and delivery (or 'shuttle') to the nucleus.

About GenScript Biotech Corporation
GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Based on its leading gene synthesis technology, GenScript has developed four major platforms including the global cell therapy platform, the biologics contract development and manufacturing organization (CDMO) platform, the contract research organization (CRO) platform, and the industrial synthesis product platform.

GenScript was founded in New Jersey, USA in 2002 and listed on the Hong Kong Stock Exchange in 2015. GenScript's business operation spans over 100 countries and regions worldwide, with legal entities located in the USA, mainland China, Hong Kong, Japan, Singapore, the Netherlands, and Ireland. GenScript has provided premium, convenient, and reliable products and services for over 100,000 customers.

Spotlight

The overall strategy of 12th Five-Year Plan is to aaccelerate the pace of research, innovation and development.The government plans to strengthen regulatory science and infrastructure, which involves setting up the Biotechnology Regulatory Authority of India (BRAI) and a central agency for regulatory testing and certification of laboratoriesThe plan also entails expanding and commissioning new bioclusters at Faridabad, Mohali, Kalyani and Hyderabad

Spotlight

The overall strategy of 12th Five-Year Plan is to aaccelerate the pace of research, innovation and development.The government plans to strengthen regulatory science and infrastructure, which involves setting up the Biotechnology Regulatory Authority of India (BRAI) and a central agency for regulatory testing and certification of laboratoriesThe plan also entails expanding and commissioning new bioclusters at Faridabad, Mohali, Kalyani and Hyderabad

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