Genetic Cancer Patients Report COVID-19 Crisis Impacts Medical Care

VHL Alliance | April 22, 2020

New research shows patients with von Hippel-Lindau (VHL) disease, a genetic oncological disorder, are experiencing delay and cancellation of important appointments and even surgery due to the COVID-19 public health crisis. For many people with rare diseases, these effects may be life-changing, particularly for otherwise young and healthy patients who may face irreversible damage as a result of delayed treatment. VHL, or von Hippel-Lindau disease, is a genetic disorder characterized by tumors in up to ten areas of the body. Under normal conditions, the VHL gene controls the cell's oxygen sensing mechanism, keeping cancerous tumors at bay. When the gene is missing or mutated, the body's tumor suppressor signaling does not function correctly. The tumors can be benign or cancerous, and appear and grow unpredictably throughout a patient's life.

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This infographics related to the biotechnology in microbiology. It is related to the Infection

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This infographics related to the biotechnology in microbiology. It is related to the Infection

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Ori Biotech Raises $30 Million $30 Million Series A Financing Round to Advance Innovation in Cell and Gene Therapy Manufacturing

Ori Biotech | October 15, 2020

Ori Biotech Ltd (Ori), a leading innovator in cell and gene therapy (CGT) manufacturing, today announced the successful close of a $30 million Series A financing round, bringing the company's total funding to date to $41 million. The new funding will be used to help bring Ori's innovative manufacturing platform to the market. The Ori platform delivers scalable solutions to flexibly address the critical clinical and commercial manufacturing needs of CGT developers. The Series A investor syndicate was led by the experienced life sciences investment team at Northpond Ventures, a leading global science, medical, and technology-driven venture fund, alongside Octopus Ventures, a leading European venture fund. Northpond and Octopus invested alongside significant support from Ori's existing institutional investors, Amadeus Capital Partners, Delin Ventures, and Kindred Capital. "Closing a significant Series A round, during these uncertain times, further validates Ori's disruptive approach to fully automating cell and gene therapy manufacturing to increase throughput, improve quality, and decrease costs," said Jason C. Foster, CEO of Ori Biotech. "We are excited to work with our top tier investors and development partners to bring our platform to market as fast as possible to achieve our mission of enabling patient access to life-saving cell and gene therapies." "As early investors in disruptive life sciences platform technology companies, we have seen how cutting-edge technologies like Ori's can bring significant value to the industry and lead to breakthroughs for patients," said Michael Rubin, M.D., Ph.D., Founder and CEO of Northpond Ventures. "We believe that the Ori team has developed a truly innovative technology that can enable millions of patients to gain access to these important treatments." Ori's bespoke platform was designed specifically to address the unique requirements of a new generation of personalized cell and gene therapies. By fully automating and standardizing CGT manufacturing in a closed platform, Ori offers therapeutics developers the opportunity to seamlessly scale from pre-clinical process development to commercial-scale manufacturing. Its flexible platform enables increased throughput, improved quality, and decreased costs.

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AI

Peptilogics and Cerebras Systems Partner on AI Solutions to Advance the Future of Peptide Therapeutics

Cerebras Systems , Peptilogics | August 19, 2021

Cerebras Systems, the pioneer in high performance artificial intelligence (AI) compute, and Peptilogics, a biotechnology platform company and an emerging leader in leveraging computation to design novel therapeutics, today announced a collaboration to accelerate the development cycle of peptide therapeutics through AI. Leveraging the revolutionary Cerebras CS-2 system – powered by the world’s fastest AI processor – Peptilogics will be able to push the boundaries of innovation in drug design and novel peptide therapeutics. This cutting-edge exploration of innovation is a scientific game changer with the potential to meaningfully reduce the time from bench to bedside. “Our mission at Peptilogics is to radically alter drug development and realize the full potential of peptides as therapeutics,” said Nick Nystrom, PhD, SVP and Head of Computation and Data, Peptilogics. “By partnering with Cerebras, we will be able to accelerate our research by orders of magnitude for important areas such as membrane proteins, including G protein coupled receptors (GPCRs). Traditional drug discovery operates on the time scale of one new drug in ten years. We aim to flip that to ten new leads in one year.” Peptides are sequences of amino acids, essentially small proteins, that play critical roles in how our bodies operate. They offer relatively unexplored opportunities for therapeutics, conferring potential advantages over other types of drugs. The “design space,” or number of possible peptide structures, is vastly larger than could be explored through traditional drug discovery. AI – specifically deep learning – is well-suited to identify ideal peptide structures as drug candidates. Through this collaboration, Cerebras and Peptilogics scientists will use the CS-2 system to develop and run advanced models to identify novel peptide therapeutics that meet specific biological activity and biophysical criteria. By accelerating the slowest step of the research cycle and training deep learning models on big data, Peptilogics with Cerebras will be positioned to deliver better therapeutics sooner. Peptilogics joins other life science leaders, including GSK and AstraZeneca, in leveraging Cerebras’ industry-leading AI technology to advance drug discovery. “Peptilogics is operating at the forefront of AI-enabled drug design. With Cerebras, they are part of a select group of partners that share similar interests in pushing the boundaries of scientific research and AI computing to radically accelerate innovation for better healthcare outcomes,” said Andy Hock, VP of Product at Cerebras. “Cerebras Systems makes world-leading AI compute accessible and easy to use so that our partners at Peptilogics can test more ideas quickly, reduce the cost of curiosity, and achieve their mission of discovering peptide therapeutics in record time.” About Cerebras Systems Cerebras Systems is a team of pioneering computer architects, computer scientists, deep learning researchers, and engineers of all types. We have come together to build a new class of computer to accelerate artificial intelligence work by three orders of magnitude beyond the current state of the art. The CS-2 is the fastest AI computer in existence. It contains a collection of industry firsts, including the Cerebras Wafer Scale Engine (WSE-2). The WSE-2 is the largest chip ever built. It contains 2.6 trillion transistors and covers more than 46,225 square millimeters of silicon. By comparison, the largest graphics processor on the market has 54 billion transistors and covers 815 square millimeters. In artificial intelligence work, large chips process information more quickly producing answers in less time. As a result, neural networks that in the past took months to train, can now train in minutes on the Cerebras CS-2 powered by the WSE-2. About Peptilogics Peptilogics is a clinical-stage biotechnology platform company that designs and develops novel peptide therapeutics. The company is supported by investors including Presight Capital, Founders Fund, and Peter Thiel, who are known for their investments in companies such as AbCellera (NASDAQ: ABCL), Compass Pathways (NASDAQ: CMPS), SpaceX, and Synthego. Through its computational platform, Peptilogics is advancing drug discovery to uncover new, previously unexplored chemical design space, while ensuring biological viability and scalable manufacturing. Peptilogics’ anti-infectives pipeline includes a novel clinical stage anti-infective, PLG0206, that has been granted FDA Orphan Drug Designation and Qualified Infectious Disease Product Designation for its initial focus on the treatment of prosthetic joint infections, an urgent unmet medical need.

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INDUSTRIAL IMPACT

BeiGene Announces Launch of Bioisland Innovation Center

BeiGene | December 27, 2021

BeiGene, a global, science-driven biotechnology company focused on developing innovative and affordable medicines, announced the official launch of the BeiGene Bioisland Innovation Center in Guangzhou, China to enable scientists and entrepreneurs to accelerate development of highly differentiated, cutting-edge medical innovations. The BIC is an innovator-centric incubator built on BeiGene’s goal of supporting exploration of new paths to meet patient needs around the world. “Over a decade ago, we started BeiGene’s journey by following the science and have grown to be a global biotechnology company with capabilities across the full value chain. With the BIC, we are supporting entrepreneurs with similar purpose and vision of delivering innovation that will benefit more patients worldwide. We expect the center will also contribute to our innovation pipeline,” John V. Oyler, Co-Founder, Chairman and CEO of BeiGene “Science and innovation are BeiGene’s core strengths. We are committed to supporting entrepreneurs incubate bold, new ideas into impactful programs that will create value for patients and benefit patients globally,” added Xiaodong Wang, M.D., Co-Founder of BeiGene, Chairman of the Company’s Scientific Advisory Committee. “With our scientific research, unique clinical development capabilities, and footprint, BeiGene is well positioned to explore new paths of innovation and support new talents in the booming biotechnology hub of Guangzhou’s Greater Bay Area.” Innovator-Centric Incubator to Accelerate Growth and Possibilities The BIC is located in the Guangdong-Hong Kong-Macau Greater Bay Area, an emerging global biotechnology hub, and will feature a comprehensive research infrastructure and professional management team. The incubator will be equipped with state-of-the-art laboratory infrastructure and comprehensive research capabilities that enable scientists and entrepreneurs to get their ideas off the ground. In addition, scientists and entrepreneurs at the BIC will have potential access to support from BeiGene on full industry value chain integration. The comprehensive, advanced technology platform at the BIC will allow innovators more autonomy in development, and integrated services to position them for growth. “The BIC is focused on cultivating entrepreneurship for new biotech companies with a passion for transformational medicines, diagnostics and medical devices that can help address unmet needs, and advancing breakthrough innovations from early discovery to being accessed by patients all over the world,” said Jonathan Liu, Chief Executive of Bioisland Initiative and Chairman of the Board of BeiGene Biologics Co., Ltd. Dr. H. Fai Poon. CEO of Zhongshan Quacell Biotechnology Co., Ltd., which is part of the innovation center, commented, "We share the same beliefs of the model and concept of the BeiGene Bioisland Innovation Center. This kind of international collaboration not only accelerates technical innovation for small and medium-sized enterprises, but also provides suitable platforms and resources to commercialize these innovations. For Quacell, which also has the 'innovative DNA', to be part of the BIC provides the opportunity to communicate and cooperate with many innovative companies in different fields around the world. We look forward to creating a common path for each other's future research and development. And we believe that this path leads to infinite possibilities to upgrade and even revolutionize the industry." About BeiGene BeiGene is a global, science-driven biotechnology company focused on developing innovative and affordable medicines to improve treatment outcomes and access for patients worldwide. With a broad portfolio of more than 40 clinical candidates, we are expediting development of our diverse pipeline of novel therapeutics through our own capabilities and collaborations. We are committed to radically improving access to medicines for two billion more people by 2030. BeiGene has a growing global team of approximately 8,000 colleagues across five continents.

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