Gene-editing tool CRISPR/Cas9 shown to limit impact of certain parasitic diseases

Medical Xpress | January 15, 2019

For the first time, researchers at the George Washington University (GW), together with colleagues at institutes in Thailand, Australia, the U.K. and the Netherlands, and more, have successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for schistosomiasis and for liver fluke infection, which can cause a diverse spectrum of human disease including bile duct cancer. Their findings are found in two papers published today in the journal eLife.
"The genes we 'knocked out' using CRISPR/Cas9 resulted in markedly diminished symptoms of infection in our animal models," said Paul Brindley, Ph.D., professor of microbiology, immunology, and tropical medicine at the GW School of Medicine and Health Sciences, and lead author. "Our research also showed that this revolutionary new biomedical procedure—CRISPR/Cas9—can be adapted to study helminth parasites, which are a major public health problem in tropical climates."

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Spotlight

Ms.Bhawana was a B.Tech Biotech fresher and she was confused about her choice of career options. She visited us and on our expert advice, she joined our 6 months “Advance Post Graduate Diploma in Clinical Research Clinical Data Management and SAS.” .We trained her 3 months classroom and for 3 months internship she was selected by MaxNeeman CRO Delhi, as Clinical Research Coordinator.
Bhawana is happy to find new career path and more confident too.

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