FUJIFILM Diosynth Biotechnologies Enters Strategic Partnership With OXGENE™ To Address Supply Bottlenecks In Gene Therapy Development & Manufacturing

FUJIFILM Diosynth Biotechnologies | April 23, 2020

FUJIFILM Diosynth Biotechnologies (FDB), a world leading cGMP Contract Development and Manufacturing Organization (CDMO) supporting its partners in the biopharmaceutical industry with the development and production of their biologics, vaccines and gene therapies, announced a strategic partnership with OXGENE™, an industry leader in the design and development of gene therapy technologies. This partnership will enable FDB to deliver gene therapy products to clients with an approximate 25% lead-time reduction. FDB has licensed OXGENE's proprietary AAV system for commercial use, to support biotech companies engaged in gene therapy development and manufacture. The AAV system consists of Helper, Rep/Cap and Gene of Interest plasmids, used in combination with a clonal suspension a HEK293 cell line. Every aspect of OXGENE's AAV system, including reconfiguration of the Rep and Cap genes, and clonal cell line selection, has been optimised for maximum AAV yield. FDB will manufacture and stock a supply of Helper and Rep /Cap plasmids for clients engaged in process development and GMP manufacture of gene therapy programs at FDB's College Station, Texas site. Gene of Interest (GOI) plasmid manufacture will be performed in-house using FDB's existing leading microbial capabilities and facilities with cGMP manufacture planned to commence in Q4 2020.

Spotlight

New medicines and diagnostics on the one hand and rising cost pressure as a result, for example, of the launch of generics and biosimilars on the other mean that new, highly efficient methods are required in biopharmaceutical production. In order to meet these challenges, Sartorius Stedim Biotech has developed membrane filters for prefiltration. In particular, the new Sartoguard generation of prefilters makes it possible to optimize existing prefiltration processes for upstream and downstream areas, but also to efficiently develop completely new production processes.

Spotlight

New medicines and diagnostics on the one hand and rising cost pressure as a result, for example, of the launch of generics and biosimilars on the other mean that new, highly efficient methods are required in biopharmaceutical production. In order to meet these challenges, Sartorius Stedim Biotech has developed membrane filters for prefiltration. In particular, the new Sartoguard generation of prefilters makes it possible to optimize existing prefiltration processes for upstream and downstream areas, but also to efficiently develop completely new production processes.

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iXCells Biotechnologies | September 30, 2022

iXCells Biotechnologies a high growth provider of cell-based products and discovery services to the academic, biotech and pharmaceutical communities worldwide, with special focus on primary and induced pluripotent stem cell derived cellular models, today announced receiving a growth investment from Connecticut-based Great Point Partners a private investment firm focusing on the healthcare industry. “iXCells is delighted to join GPP’s portfolio of companies operating within the rapidly growing biotech manufacturing and DD&D services space. We’re grateful for GPP’s support of our vision to translate human cell technology into innovative solutions that advance cell biology research and drug discovery. Our partnership with GPP is a critical step forward for our Company’s growth journey.” Dr. Lynn Zhang, CEO and co-founder iXCells President and co-founder, Dr. Nianwei Lin added, “Our customers will clearly benefit from the deployment of additional capital towards key growth initiatives that will increase iXCells’ operational capacity, expand our product/service offering and bioanalytical capabilities. In particular, we’ll be strengthening our ability to service unmet market needs in areas of personalized medicine including rare diseases. We’re very much looking forward to collaborating with GPP’s management team and broad network to advance iXCells’ mission for the benefit of all stakeholders.” Noah Rhodes, Managing Director at GPP, commented, “Lynn and Nianwei have done an exceptional job building a rapidly growing company serving academic, biotech and pharma clients with best-in-class drug discovery solutions and disease-relevant cellular models. We were extremely impressed by the scientific expertise the management team has built within the organization, and we look forward to helping them expand their product and service offering into adjacent high-growth end markets.” About iXCells Biotechnologies Founded in 2014 and based in San Diego, CA, iXCells Biotechnologies is an innovative cell biology and cell technology company that provides preclinical drug discovery solutions with the focus on disease relevant cellular models enabling technologies and services to the academic, biotech and pharma communities to accelerate the pace of drug discovery. iXCells offers customers access to high quality primary and iPSC derived cells, custom iPSC services, functional bioassay development and drug screening. About Great Point Partners Great Point Partners, founded in 2003 and based in Greenwich, CT, is a leading health care investment firm with 30 professionals, investing in the United States, Canada, and Western Europe. GPP is currently making new minority and majority private equity investments from GPP IV. Great Point manages $1.5B of capital in its private funds and public life sciences equity strategy (BioMedical Value Fund). Great Point Partners has provided growth equity, growth recapitalization, and management buyout financing to more than 200 growing health care companies. The private equity funds invest across all sectors of the health care industry with a particular emphasis on biopharmaceutical services and supplies, alternate site care, medical device and information technology enabled businesses. The firm pursues a proactive and proprietary approach to sourcing investments and tuck-in acquisitions for its portfolio companies.

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Rocket Pharmaceuticals Completes Acquisition of Renovacor

Rocket Pharmaceuticals, Inc. | December 02, 2022

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New Data Reveal Molecular Drivers of Thyroid Eye Disease (TED) May Remain Activated In Patients with Low Clinical Activity Score (CAS)

Horizon | October 03, 2022

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