First phase 3 data back Scynexis' new-class antifungal

Questex LLC | January 31, 2019

The results come from the first 20 of a planned 60 patients in the FURI trial, which is focusing on invasive yeast infections caused by Candida species in patients that have failed multiple antifungal therapies and are at high risk of dying. It showed that oral dosing of ibrexafungerp (previously known as SCY-078) as a "salvage" therapy showed evidence of efficacy in 17 of them, with 11 complete or partial responders and six people whose disease stabilized. Fungal infections claim an estimated 1.5 million deaths each year, but only a handful of drug classes have been successfully developed for the treatment of life-threatening, invasive fungal diseases including polyenes like amphotericin B, azoles such as fluconazole and echinocandins including Merck’s Cancidas (caspofungin) and Astellas’ Mycamine (micafungin).
That means there is an undeniable need for new treatment options, particularly as some fungal species such as Candida glabrata and C. Auris have been identified that are resistant to both azoles and echinocandins. The FURI trial mainly involved infections caused by C. glabrata and C. krusei, organisms prone to antimicrobial resistance. Ibrexafungerp is a member of the glucan synthase inhibitor class but has a novel triterpenoid structure that Scynexis says combines high antifungal activity with the potential to be delivered both intravenously and orally.

Spotlight

Meet the NeatCell C-Pro application. It automates the mononuclear cell fraction enrichment from diverse cellular products, and is designed for use with a density-gradient medium like Ficoll-Paque media with the Sepax C-Pro instrument and CT-90.1 single-use kit.

Spotlight

Meet the NeatCell C-Pro application. It automates the mononuclear cell fraction enrichment from diverse cellular products, and is designed for use with a density-gradient medium like Ficoll-Paque media with the Sepax C-Pro instrument and CT-90.1 single-use kit.

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