Fetal signaling pathways may offer future targets for treating lung injury

Medical Xpress | February 18, 2019

Specialized lung cells appear in the developing fetus much earlier than scientists previously thought. A new animal study published this week in the Proceedings of the National Academy of Sciences reports how cells that become alveoli, the tiny compartments in which gas exchange occurs in the lung, begin their specialized roles very early in prenatal life. The researchers from the Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia (CHOP) say that investigating the fetal signaling pathways active in this biological event may offer future opportunities to treat lung damage caused by prematurity and other lung injuries.
The research team focused on the basic function of respiration—the exchange of oxygen and carbon dioxide within key cells called alveolar type 1 and type 2 cells. The same research team previously identified a new cell lineage in the lungs of mice and humans, which they called alveolar epithelial progenitor cells. The new research used single-cell RNA sequencing analysis, protein expression studies, and a new lineage-tracing tool to reveal details of early lung formation in a fetal mouse model. Edward E. Morrisey, Ph.D., director of the Penn Center for Pulmonary Biology, Rajan Jain, MD, an assistant professor of Cardiovascular Medicine at Penn, and David B. Frank, MD, Ph.D., a pediatric cardiologist at CHOP, were co-authors on the study.

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Intact Genomics, Inc. is located in the Helix Center Biotech Incubator in St. Louis, Missouri, USA, a national and international center of medicine & biotechnology. We offer Competent Cells, Enzymes and custom genomic services.

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Intact Genomics, Inc. is located in the Helix Center Biotech Incubator in St. Louis, Missouri, USA, a national and international center of medicine & biotechnology. We offer Competent Cells, Enzymes and custom genomic services.

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Elastrin Therapeutics Inc. | January 17, 2022

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After a postdoctoral research fellowship at the University of California, San Diego, he became the leader of an independent research group at Münster University Children’s Hospital in 2004. Dr. Rutsch’s main research interests are focused on the discovery of the underlying genetic defects and translational aspects in rare pediatric metabolic and autoimmune disorders. Dr. Klaus-Dieter Langner: Klaus-Dieter Langner is a life science expert with more than 32 years of experience in pharmaceutical industry. Klaus started his career as research scientist at Behringwerke/Hoechst focusing on the expression of recombinant human plasma proteins and immunomodulators. After 12 years, he moved to Grünenthal where he was appointed as Head of Research. In his last position, Klaus acted as Chief Scientific Officer and Member of the Corporate Executive Board. Prof. Linda Hands, MD: Linda Hands was appointed Clinical Reader in the University of Oxford and Honorary Consultant Vascular surgeon in 1992 after training in London, Oxford and Chicago. She was Clinical Director of Vascular and cardiothoracic surgery for three years and also served on the Health Authority and a NICE committee. Linda retired in late 2017 as Associate Professor and remain an Hon. Emeritus Professor at the John Radcliffe Hospital Oxford and Emeritus Fellow of Green College, Oxford. Dr. Pedro M. Quintana Diez, M.D.: Pedro is an internal medicine doctor with over 20 years of clinical development experience in the international biotech and pharmaceutical industry. Prior to joining Elastrin Therapeutics, Pedro served as CMO of Sensory Sciences LLC and held VP and leadership positions at Grunenthal, Abbvie and ParinGenix. Pedro managed Phase II and III developments in cardiovascular and lung diseases. 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PR Newswire | August 21, 2020

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