Exclusive: BeyondSpring’s Plinabulin Reduces Bone Pain in CIN Patients

biospace | May 20, 2019

Lin Huang, chief executive officer of BeyondSpring, believes her company has the “secret sauce” that could provide beneficial treatment to chemotherapy-induced neutropenia, a common side effect for chemotherapy patients. Huang is talking about her company’s lead asset Plinabulin, a marine-derived small molecule that sequesters tubulin heterodimers. Plinabulin, Huang said, is a potential disruptor in treatment for these conditions. The drug is being studied as a potential therapy for the treatment of chemotherapy-induced neutropenia (CIN). BeyondSpring will take clinical data into the American Society of Clinical Oncology (ASCO) and show off the efficacy and safety of the therapeutic as a treatment for CIN. Neutrophils are a type of white blood cell that fights infections in the body. CIN occurs when neutrophils are not being produced due to the effects of chemotherapy. CIN increases a patient's risk of infection and disrupts their cancer treatment. While Plinabulin was being developed as an anti-cancer agent, Huang told BioSpace that it was interesting for BeyondSpring researchers to discover the drug’s effects on CIN. Current treatment for CIN prevention is G-CSF monotherapy such as Neulasta, but that has serious limitations, Huang said. In fact, many of the patients who receive high-risk chemotherapy and G-CSF monotherapy can still experience Grade 3 or 4 CIN. When these Grades of CIN appear, it forces doctors to reduce the dose of chemotherapy, thereby slowing treatment for the cancer. Doctors can also choose to discontinue the treatment process, which significantly lowers survivor outcome, she said.

Spotlight

Biotechnology has the power to increase human health, environmental sustainability and the wellbeing of consumers and farm communities globally. For example, higher yielding crops developed through agricultural biotechnology can contribute toward meeting the United Nation’s estimated need for a 50 percent increase in world food production by 2030.

Spotlight

Biotechnology has the power to increase human health, environmental sustainability and the wellbeing of consumers and farm communities globally. For example, higher yielding crops developed through agricultural biotechnology can contribute toward meeting the United Nation’s estimated need for a 50 percent increase in world food production by 2030.

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