CELL AND GENE THERAPY, INDUSTRIAL IMPACT
Bio-Techne Corporation | March 20, 2023
Bio-Techne Corporation announced it has completed its participation in the Cell and Gene Therapy Catapult Process Analytical Technology (Catapult PAT) consortium, a multi-year collaboration involving 24 partner companies, technology providers, therapy developers, and charities. The Catapult PAT consortium is the first initiative of this scale and functional expertise with member companies and organizations collaborating to develop cell and gene therapy-specific process analytical technologies.
The PAT initiative began in January 2021 with a series of experiments designed to monitor process parameters of an exemplar 8-day T-cell expansion bioprocess using primary T-cells. Data were gathered from five independent analyses to generate an extensive, world-first dataset. An analysis of multiple cytokine targets was conducted using high-plex Luminex® immunoassays and the precision multiplexing Ella™ platform from Bio-Techne. The automated workflow of the Ella platform proved to be particularly amenable to the efficiency, accuracy, and throughput demands inherent in a bioprocess manufacturing environment. With its robust performance in this project, the Cell and Gene Therapy Catapult plans to incorporate Ella™ into an existing CGT Catapult facility to further support scientists in the UK.
"As a leader in the forefront of innovative tools to measure cytokines, we are honored to be a part of the Catapult PAT initiative to help advance cell and gene therapy development," said Will Geist, President of Bio-Techne's Protein Sciences Segment. "Bio-Techne remains excited about the potential of these advanced therapies to improve patient outcomes and treat a wide range of diseases that currently have very poor or ineffective treatments."
Established by Innovate UK, the Cell and Gene Therapy Catapult fosters collaborations between academia, industry, and healthcare providers to develop new technology and drive innovation. Catapult experts cover all aspects of advanced therapies, from research and development to clinical adoption and every step in between.
About Bio-Techne
Bio-Techne Corporation is a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic communities. Bio-Techne products assist scientific investigations into biological processes and the nature and progress of specific diseases. They aid in drug discovery efforts and provide the means for accurate clinical tests and diagnoses. With thousands of products in its portfolio, Bio-Techne generated approximately $1.1 billion in net sales in fiscal 2022 and has approximately 3,000employees worldwide.
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CELL AND GENE THERAPY, INDUSTRIAL IMPACT
Oxford Nanopore Technologies | February 17, 2023
On February 16, 2023, Oxford Nanopore Technologies announced that it will be furthering its collaboration with UPS Healthcare to expedite the distribution of its Oxford Nanopore DNA/RNA sequencing products and consumables throughout the Asia Pacific region.
The collaborative effort will strengthen the supply chain for Oxford Nanopore's portable, real-time DNA sequencing devices in key markets across Asia. By leveraging the specialized healthcare logistics solutions provided by UPS, Oxford Nanopore will be able to provide its customers with faster delivery times, simplifying the entire process and reducing customer pain points. In addition, this development will enable Oxford Nanopore's customers to allocate more time and resources toward high-impact, time-sensitive genomics research, particularly in critical areas such as human disease, cancer, and agriculture.
Oxford Nanopore's flow cells will be stored at UPS Healthcare's temperature-controlled distribution facility in Singapore for the first time and will be delivered within 24 to 48 hours to destinations across the Asia Pacific via UPS's cold chain distribution capabilities. For time- and temperature-sensitive shipments, Oxford Nanopore, will additionally use UPS® Premier's premium, prioritization, tracking and recovery service.
The objective will be same-day dispatch and quicker delivery of flow cells, which are consumable cartridges that include the chemistry and technology required for nanopore-based sequencing and are used in tandem with Oxford Nanopore's product range.
Oxford Nanopore's investment in the Asia Pacific demonstrates the company's ongoing commitment to supporting the area's rising client base, with several genomics-led research projects prospering across region countries. They include translational cancer research, pathogen surveillance and agricultural sequencing, most notably to preserve Malaysian shrimp farming.
With more than 17 million square feet of cGMP and GDP-compliant healthcare distribution space worldwide, UPS Healthcare provides scientific communities with unrivaled healthcare logistics expertise.
After a fulfillment deal signed in 2022 that presently covers the United States and Canada, this is Oxford Nanopore's second region served by UPS Healthcare. Plans to expand the collaboration to other parts of the world, including Australia, are expected to be announced in 2023.
About Oxford Nanopore Technologies
Founded in 2005, Oxford Nanopore Technologies has made a significant breakthrough by creating the world's first and only platform for nanopore DNA and RNA sequencing. This new generation of sequencing technology offers numerous benefits, including the ability to scale to portable or ultra-high-throughput formats, real-time data delivery, and the ability to provide detailed biological data. By offering such innovative technology, Oxford Nanopore Technologies seeks to transform traditional biological analyses and explore new applications that can positively impact society. The company now has over 600 employees with expertise in a wide range of fields, including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing, and commercialization.
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CELL AND GENE THERAPY, INDUSTRIAL IMPACT
Aldevron | January 20, 2023
Aldevron®, a worldwide leader in the custom development and production of plasmid DNA, RNA, and proteins for the biotech sector, recently announced the launch of Eureca-V™ nuclease.
Eureca-V™, licensed from Inscripta®, is the wild-type MAD7® CRISPR Type-V nuclease at research grade, with GMP to follow.
The launch of Aldevron's Eureca-V nuclease at advanced therapies week expands the toolkit of accessible CRISPR nucleases for therapeutic, diagnostic, and agricultural workflows. In addition, a pass-through license for research use is conveyed with the purchase of Eureca-V nuclease, allowing customers to thoroughly examine the product without committing to a long-term licensing agreement.
Vice President and General Manager of Aldevron's Protein Business Unit, Tom Foti, said, "The availability of Eureca-V drives forward the entire genomics medicine industry and enhances Aldevron's position as a supplier of choice for CRISPR drug substances and drug products." He added, "We are proud to work alongside our partners at Inscripta to bring the innovative, off-the-shelf catalog product to market now as well as provide a clear path to GMP in 2023."
(Source – Cision PR Newswire)
Eureca-V at the research grade level ensures the acceleration of CRISPR translational research. In addition, the product will assist academic and commercial scientists seeking a wild-type Type-V CRISPR nuclease that targets T-rich regions of the genome.
Venkata Indurthi, Chief Scientific Officer at Aldevron, expressed, "We are thrilled to offer Eureca-V product at research grade starting today, and later this year, our clients can expect a smooth transition to our GMP product." He further added, "Aldevron's extensive history in CRISPR nucleases allows researchers to develop therapies that will eventually address global health issues."
(Source – Cision PR Newswire)
It will be the third GMP CRISPR nuclease by Aldevron and the first Type-V nuclease available as a GMP catalog product. It is a leader in supplying vital raw materials and reagents used for cell and gene therapy manufacturing. The company's portfolio of CRISPR nucleases is applied globally in preclinical and clinical research applications.
About Aldevron
Aldevron is a pioneer in advancing biological science. Its custom development and manufacturing services have provided scientists all across the world with the components they need to accelerate research and create labs for revolutionary science and breakthrough discoveries. The company aims to deliver products and services that contribute significantly to global biological research. It seeks to be the partner of choice forproducing high-quality plasmid DNA, proteins, enzymes, and other biologicals to support its clients' goals.
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