Cannabis Addiction Linked to Genetic Variants

genengnews | April 24, 2019

A study in human volunteers has found that some individuals may be genetically more predisposed to cannabis addiction than others. The research, headed by a team at University College London (UCL), linked specific variants in the cannabinoid receptor 1 (CNR1) gene and in the fatty acid amide hydrolase (FAAH) gene with behavioral measures of addiction predisposition, or endophenotypes, which are typical of cannabis use disorders (CUD). “We were interested in asking whether these genetic markers could predict addiction-related responses after inhaling doses of cannabis, such as how much our attention is drawn to cannabis-related pictures,” said lead researcher Chandni Hindocha, PhD, a post-doctoral research associate at UCL’s Clinical Psychopharmacology Unit. The researchers report on their studies in Addiction Biology, in a paper titled, “Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme.”

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Biodegradation is the action of microorganisms to decompose a substance into its constituent elements or new compounds. This is the key process by which biodegradable plastics are broken down in the environment.

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Biodegradation is the action of microorganisms to decompose a substance into its constituent elements or new compounds. This is the key process by which biodegradable plastics are broken down in the environment.

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