Allogene, Notch Partner to Develop iPSC-Derived Blood Cancer Therapies

GEN | November 05, 2019

Allogene, Notch Partner to Develop iPSC-Derived Blood Cancer Therapies
Allogene Therapeutics will partner with Notch Therapeutics to research and develop induced pluripotent stem cell (iPSC) AlloCAR™ therapies for initial blood cancer indications that include non-Hodgkin lymphoma, leukemia and multiple myeloma, the companies said today, through an exclusive worldwide collaboration and license agreement that could generate more than $300 million for Notch. Under their partnership, Allogene and Notch plan to create allogeneic cell therapy candidates from T cells or natural killer (NK) cells using Notch’s Engineered Thymic Niche (ETN) platform, created to offer potential flexibility and scalability for the production of stem cell-derived immune cell therapies. ETN is designed to enable the expansion of induced pluripotent stem cells (iPSCs) and differentiation of iPSCs from mature immune cells in scalable, fully defined, feeder-free and serum-free cultures into T cells that can be genetically tailored for any T cell-based immunotherapeutic application. The platform uses genetically tailored stem cells as a renewable source for creating allogeneic T cell therapies that are designed, according to Notch, to deliver safer, consistently manufactured and more cost-effective cell immunotherapies to patients.

Spotlight

North Carolina’s longstanding commitment to biotechnology has played a key role in establishing a large and growing life science industry in the state. While job creation has been in decline for many of the state’s traditionally strong industries, jobs in North Carolina’s life science industry increased 29% from 2001 to 2008 with an average pay in 2008 of $74,829, which is 90% higher than the state’s average private sector wages.

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North Carolina’s longstanding commitment to biotechnology has played a key role in establishing a large and growing life science industry in the state. While job creation has been in decline for many of the state’s traditionally strong industries, jobs in North Carolina’s life science industry increased 29% from 2001 to 2008 with an average pay in 2008 of $74,829, which is 90% higher than the state’s average private sector wages.