Drugs & Diagnostics for Tropical Diseases

Medical Xpress | September 20, 2018

Scientists have found a way to boost the efficacy of the world's most powerful antimalarial drug with the help of chemotherapy medicines, according to new research published in the journal Nature Communications. Scientists from the University of Melbourne and the Japanese pharmaceutical company Takeda have discovered that antimalarial drug artemisinin works through a "double whammy" attack on the deadly parasite. The drug damages proteins in malaria parasites and clogs the p...

Questex LLC | November 16, 2018

Novartis’ Farydak was approved by the FDA to treat multiple myeloma in 2015. Now scientists in Australia believe the drug can be combined with an early-phase clinical agent to tackle neuroblastoma, a type of nerve tissue cancer mostly seen in young children. Professor Murray Norris and his colleagues at the Children’s Cancer Institute Australia for Medical Research tested Farydak in combination with an investigational drug called CBL0137 in a mouse model of neuroblastoma. In mice tha...

ScienceDaily | March 13, 2018

"This not only advances our understanding of how the body responds to cold, but could lead to new ways to control the amount of brown fat in the body, which has links to obesity, diabetes and fatty liver disease," says senior author Ronald Evans, Howard Hughes Medical Institute investigator and holder of Salk's March of Dimes Chair in Molecular and Developmental Biology....

Labiotech.eu | January 28, 2020

A Swiss research group has developed tiny plastic particles that could carry gene therapies to the center of the cell with less risk of getting attacked by the immune system than conventional gene therapies. The majority of gene therapies in use today are delivered to the DNA of target cells using viral vectors. While efficient at their job, viral vectors can risk triggering the immune system to destroy them. This can lead to the therapy becoming ineffective....