WHO berates 'lack of innovation' when it comes to antibiotic pipeline

| January 21, 2020

article image
The World Health Organization (WHO) has called out Big Pharma for its dearth of antibiotic innovation amid a growing threat of antimicrobial resistance (AMR). Two new reports out—"Antibacterial Agents in Clinical Development - An Analysis of the Antibacterial Clinical Development Pipeline" and its companion publication, "Antibacterial Agents in Preclinical Development - An Open Access Database"—have highlighted “a weak pipeline for antibiotic agents,” WHO said, with the 60 products in development (50 antibiotics and 10 biologics) bringing “little benefit over existing treatments and very few target the most critical resistant bacteria (Gram-negative bacteria).”

Spotlight

Torrent Pharmaceuticals Ltd

Torrent Pharma, with a market cap of over Rs. 20,000 cr, is a flagship company of the Torrent Group. It is ranked among the top pharma companies of India. It is a dominant player in the therapeutic areas of cardiovascular (CV) and central nervous system (CNS) and has achieved significant presence in gastro-intestinal, diabetology, anti-infective and pain management segments. It has also forayed into the oncology and nephrology segments while also strengthening its focus on gynecology and nutraceuticals segments. Torrent Pharma’s competitive advantage stems from its world-class manufacturing facilities located at Indrad and Dahej in Gujarat, Baddi in Himachal Pradesh and Sikkim in North East, advanced R&D capabilities, extensive domestic network and a widespread global presence across 40 countries.

OTHER ARTICLES
MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

Read More
DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

Read More

Spotlight

Torrent Pharmaceuticals Ltd

Torrent Pharma, with a market cap of over Rs. 20,000 cr, is a flagship company of the Torrent Group. It is ranked among the top pharma companies of India. It is a dominant player in the therapeutic areas of cardiovascular (CV) and central nervous system (CNS) and has achieved significant presence in gastro-intestinal, diabetology, anti-infective and pain management segments. It has also forayed into the oncology and nephrology segments while also strengthening its focus on gynecology and nutraceuticals segments. Torrent Pharma’s competitive advantage stems from its world-class manufacturing facilities located at Indrad and Dahej in Gujarat, Baddi in Himachal Pradesh and Sikkim in North East, advanced R&D capabilities, extensive domestic network and a widespread global presence across 40 countries.

Events