The Latest Advancements in Metabolomics

MOLLY CAMPBELL | November 5, 2019

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Metabolomics is a field dedicated to the study of small molecules, or metabolites, present in a biological system. Analysis of the metabolites present within an organism (the metabolome) or cell provides a chemical fingerprint of its physiological status. Characterizing the metabolome has a wide range of applications in a number of fields, from nutrition and food science, to understanding human disease. The applications of this rapidly growing field are only set to expand as analytical technologies continue to advance and increase in capability. To find out more about the recent advances in metabolomics and the technologies that have evolved alongside it, we spoke with Lucy Woods, Global Technology Leader at Bruker Daltonics.

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Vision Mark Biotech

VISION MARK BIOTECH is a multidimensional fast growing biotech company, established with an objective to provide excellent quality biotechnology based products and services to our customers in safer, cost effective and responsible manner. Vision Mark Biotech has encouraged by first of its kind concept as “Progress through combination of integrity and technology”.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Vision Mark Biotech

VISION MARK BIOTECH is a multidimensional fast growing biotech company, established with an objective to provide excellent quality biotechnology based products and services to our customers in safer, cost effective and responsible manner. Vision Mark Biotech has encouraged by first of its kind concept as “Progress through combination of integrity and technology”.

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