Parade Gene Controls Pigment Stem Cells in Zebrafish

| March 1, 2019

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Scientists at the University of Bath have identified how a mutant gene in fish is involved in controlling stem cells. A new study from the group of Professor Robert Kelsh in the Department of Biology & Biochemistry looks at how a novel group of stem cells is controlled by mutations in a gene called the parade. They identified a new set of stem cells in zebrafish, which eventually become skin pigment cells of different colors. Populations of pigment stem cells are formed in the embryonic stages of development, but are then dormant and don’t mature into a final cell type until adulthood. 

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

The Private Healthcare Company

The Private Healthcare Company Limited are an independent health insurance intermediary with clients throughout the UK and overseas. At the Private Healthcare Company Limited we are very proud of our independent status. Rather than just working for one insurer we work on behalf of our customers, researching the market to find the health insurance products that best suit their requirements. We can provide assistance on a range of different health insurance products including private medical insurance, dental cover and income protection. Additionally we represent all the leading insurers including Bupa, Axa PPP Healthcare, Standard Life Healthcare and WPA as well as the smaller, specialist insurers that offer products exclusively through intermediaries

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