Liver Hormone Puts the Brakes on Metabolism

UNIVERSITY OF MICHIGAN LIFE SCIENCES INSTITUTE | January 15, 2019

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Researchers at the University of Michigan Life Sciences Institute have identified a hormone produced by the liver that tells the body to downshift its metabolism when it’s expending a lot of energy. The research, published in Nature Metabolism, reveals a potential target for treating metabolic disorders. Our bodies use several systems to maintain precise control of energy homeostasis balancing the amount of energy we use and the calories we consume.

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Rambam Healthcare Campus is Northern Israel’s foremost and largest hospital, and both the landmark and standard of quality for healthcare in the region. Rambam is a referral center for eleven hospitals in the region and serves over two million citizens of Northern Israel, a population unique in its religious, cultural and socio-economic diversity. With 1000 beds, departments in every medical specialty, and a highly distinguished professional staff, Rambam delivers the full spectrum of healthcare services, and is the exclusive provider in Northern Israel for trauma treatment, oncology, neurosurgery and molecular imaging. Rambam’s Children’s Hospital is the leading pediatric medical services provider in the North.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Rambam Health Care Campus

Rambam Healthcare Campus is Northern Israel’s foremost and largest hospital, and both the landmark and standard of quality for healthcare in the region. Rambam is a referral center for eleven hospitals in the region and serves over two million citizens of Northern Israel, a population unique in its religious, cultural and socio-economic diversity. With 1000 beds, departments in every medical specialty, and a highly distinguished professional staff, Rambam delivers the full spectrum of healthcare services, and is the exclusive provider in Northern Israel for trauma treatment, oncology, neurosurgery and molecular imaging. Rambam’s Children’s Hospital is the leading pediatric medical services provider in the North.

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