Like Genes, Our Microbes Pass from Parent to Child

| March 7, 2019

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We all know that our parents pass on heritable traits, including skin color and height, to us through their genes. Now, the Human Microbiome Project - a department of the National Institute of Health - has produced findings to suggest that our microbial genes are also transmitted vertically from our ancestors. Before we explore this exciting discovery, let’s start with some basics:

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HEI Health is a healthcare re-engineering organization whose passion, over the last 20 years, has been solving the most complex and challenging problems faced in healthcare. Whether it is improving patient's experience and access to care, solving the challenge of physician burnout, implementing a one-stop does it all “schegistration” model or improving revenue cycle collections, our team of experts can lead you towards the solutions you want.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

HEI Health

HEI Health is a healthcare re-engineering organization whose passion, over the last 20 years, has been solving the most complex and challenging problems faced in healthcare. Whether it is improving patient's experience and access to care, solving the challenge of physician burnout, implementing a one-stop does it all “schegistration” model or improving revenue cycle collections, our team of experts can lead you towards the solutions you want.

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