Keys to Better Liquid Biopsy Assay Sensitivity

| February 14, 2019

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“So as everyone here is aware, I’m sure, detection of circulating tumor DNA is challenging. There’s very little of it, to start with.” Hardly a revolutionary statement by Tony Godfrey, Ph.D., (Associate Chair, Surgical Research and Associate Professor of Surgery, Boston University School of Medicine) but an important acknowledgment from a leading expert of the difficulty faced by laboratorians in unlocking the full promise of liquid biopsy assays. Both he and Bob Daber, Ph.D., (President and CTO of Generosity) detailed how they overcame common ctDNA challenges in their labs during SeraCare’s AMP Corporate Workshop in San Antonio, Texas. Watch the video to see the practical advice they gave in their presentations.

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Curative Care

Curative Care is a leading community resource that provides high quality services to children, adults and senior citizens with disabilities or limiting conditions at community-based sites and natural settings in Milwaukee and surrounding counties. Our proven programs offer a variety of purposeful, goal-oriented activities and opportunities that promote independence and enrich lives. We see people for their abilities and our amazing staff works with them to improve their function and quality of life.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Curative Care

Curative Care is a leading community resource that provides high quality services to children, adults and senior citizens with disabilities or limiting conditions at community-based sites and natural settings in Milwaukee and surrounding counties. Our proven programs offer a variety of purposeful, goal-oriented activities and opportunities that promote independence and enrich lives. We see people for their abilities and our amazing staff works with them to improve their function and quality of life.

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