Is it the Age of the Bacteriophage?

| April 1, 2019

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Did you know that your average life expectancy in the 1920s would have only been age 47? That jumped to 78 after Penicillin was created in 1928, helping us gain about 30 years of life! Unfortunately, no new classes of antibiotics have been discovered since 1987 and antibiotic resistance is now reaching crisis stage. But there’s hope. Scientists around the world are realizing the next answer may be living all around (and on) us! 1  2

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Falck UK

Falck is the UK’s leading provider of Patient Transport. Operating from 7 regional headquarters nationwide, we offer a range of patient transport services including non-emergency, high dependency, renal, bariatric, urgent care and paediatric retrieval as well as A&E and front line response through our Emergency Ambulance Division. Falck in the UK is a subsidiary of the Falck Group, the global leader in emergency and ambulance services. Present across 44 countries on six continents and operating more than 2500 ambulances, Falck has the world’s largest international ambulance fleet.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Falck UK

Falck is the UK’s leading provider of Patient Transport. Operating from 7 regional headquarters nationwide, we offer a range of patient transport services including non-emergency, high dependency, renal, bariatric, urgent care and paediatric retrieval as well as A&E and front line response through our Emergency Ambulance Division. Falck in the UK is a subsidiary of the Falck Group, the global leader in emergency and ambulance services. Present across 44 countries on six continents and operating more than 2500 ambulances, Falck has the world’s largest international ambulance fleet.

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