DNA Synthesis: Tackling the Main Bottleneck in Biology Research

CLARA RODRÍGUEZ FERNÁNDEZ | November 18, 2019

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A wave of new technologies to synthesize DNA faster, cheaper and more accurately could have a far-reaching impact across all areas of biology research. Ten years ago, Sylvain Gariel was working for the French oil company Total, engineering microorganisms to produce biofuels. It was tedious work. The advent of next-generation sequencing meant that a whole human genome could be read within one day instead of several years. So why not translate that principle into DNA synthesis? Gariel and two of his colleagues at Total started looking for a way to write DNA faster, cheaper and with fewer errors. In 2014, they founded DNAScript. The goal of this company based in Paris is to develop a brand new way of writing DNA that can replace traditional chemical synthesis.

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MEDICAL

Better Purification and Recovery in Bioprocessing

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DIAGNOSTICS

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Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Healthcare Management Solutions Ltd

Centrally based just south of Birmingham, HCMS has a nationwide team of Regional Managers, all of whom have had multi-site management experience and therefore have both practical experience and knowledge of day to day care home operation. We operate the lowest ratios of homes to Regional Managers in the industry recognising the intensive nature of the service that we offer.

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