Danish Biotech to Develop CRISPR-Based Microbiome Treatments

| March 11, 2019

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SNIPR Biome has raised €43M in Series A funds to develop treatments that precisely target ‘bad’ bacteria using CRISPR gene editing while keeping the rest of the patient’s microbiome intact. Founded with €2.6M seed investment from the Lundbeck Foundation in 2017, SNIPR Biome was the first exploratory investment for the Danish organization’s Emerge fund, which focuses on investing in and developing early-stage biotechs with great potential.

Spotlight

Avant Healthcare UK

Avant Healthcare Services Ltd was created to provide quality, sustainable care services. Its foundations were based on an enviable combination of experience and knowledge gained from an owner who has more than 17 years of sustainable success in the care sector. Sally Graham started her first business in 1996 as a franchisee and quickly built up a highly successful multi-site operation covering 9 territories and turning over £12millon. Sally sold her business to one of the UK’s top five home care companies in 2010 and then began work on her new venture ably supported by Deepa Dungar, Operations Manager and a shareholder in the new operation.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Avant Healthcare UK

Avant Healthcare Services Ltd was created to provide quality, sustainable care services. Its foundations were based on an enviable combination of experience and knowledge gained from an owner who has more than 17 years of sustainable success in the care sector. Sally Graham started her first business in 1996 as a franchisee and quickly built up a highly successful multi-site operation covering 9 territories and turning over £12millon. Sally sold her business to one of the UK’s top five home care companies in 2010 and then began work on her new venture ably supported by Deepa Dungar, Operations Manager and a shareholder in the new operation.

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