Considerations for the Development of a Liquid Biopsy Assay for Cancer

HONEY REDDI | March 26, 2019

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For a liquid biopsy test, one needs to obtain DNA from the blood that is representative of the cancer. Cells shed from a growing tumour into the blood stream; circulating tumour cells (CTCs) can be isolated and used to extract DNA for the purposes of testing. A much easier way is to isolate the DNA that is released when these cells lyse to obtain cell free DNA (cfDNA). Both CTCs and cfDNA have been demonstrated to be equally viable for a liquid biopsy assay addressing these points, which brings us to the next question of what should we be looking for as we develop the content to be evaluated?

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