Coming from Behind: How Italy is Revamping its Biotech Industry

| April 13, 2017

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While ‘European biotech’ brings to mind France, Germany and the UK, Italy is cultivating its own thriving ecosystem. It claims internationally renowned scientific research institutions, including the University of Perugia and the San Raffaele Institute of Milan, which have given rise to successful spin outs such as Genenta, which works on innovative treatments for cancer.

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SignalChem

SignalChem is a biotechnology company focused on the research, development and production of innovative cell signaling products for the advancement of basic life sciences research and drug discovery efforts. Specific emphasis is placed on the production of highly purified biologically-active human recombinant proteins.SignalChem is a leader in the recombinant protein market. We strive to produce products to fulfill the needs of scientists in both academia and the biotech industry. All of SignalChem’s products are subjected to rigorous testing and quality control analyses to ensure the highest quality proteins are produced.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

SignalChem

SignalChem is a biotechnology company focused on the research, development and production of innovative cell signaling products for the advancement of basic life sciences research and drug discovery efforts. Specific emphasis is placed on the production of highly purified biologically-active human recombinant proteins.SignalChem is a leader in the recombinant protein market. We strive to produce products to fulfill the needs of scientists in both academia and the biotech industry. All of SignalChem’s products are subjected to rigorous testing and quality control analyses to ensure the highest quality proteins are produced.

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